MYBMIM
Based on 1 Customer Validation
MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.96%
- Formel: C166H296N60O45S
- Molecular Weight:3884.57
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
MYBMIM (10-20 μM) inhibits proliferation (6 days) and induces apoptosis (48 h) in acute myeloid leukemia cells by downregulating anti-apoptotic Bcl2 gene expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13, MV-411, ML2, and HL60
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Concentration:10-20 μM
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Incubation Time:6 days
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Result:Inhibited cell viability.
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Cell Line:MV-411
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Concentration:20 μM
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Incubation Time:4 h
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Result:Induced cell apoptosis.
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Cell Line:MOLM-13, MV-411, ML2, and HL60
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Concentration:10-20 μM
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Incubation Time:6 h
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Result:Downregulated levels of Bcl2
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AML-MLL- leukemia xenograft mice model[1]
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Dosage:25 mg/kg
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Administration:ip, twice a day for 14 days
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Result:Delayed leukemia progression and extended survival.
Chemical Information
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Appearance Solid
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Molecular Weight 3884.57
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Formel C166H296N60O45S
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Color White to off-white
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Sequence
Ac-d-{Lys-Leu-Glu-Asn-Glu-Thr-Ser-Met-Leu-Leu-Leu-Glu-Leu-Glu-Lys-Ile-Arg-Lys-Gly-Gly-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Tyr}-NH2
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Sequence Shortening
Ac-d-{KLENETSMLLLELEKIRKGG-RRRQRRKKRGY}-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
H2O : ≥ 50 mg/mL (12.87 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2574 mL | 1.2871 mL | 2.5743 mL | 6.4357 mL |
| 5 mM | 0.0515 mL | 0.2574 mL | 0.5149 mL | 1.2871 mL | |
| 10 mM | 0.0257 mL | 0.1287 mL | 0.2574 mL | 0.6436 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MYBMIM Related Classifications
HY-P10238 Related Classifications
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