MYBMIM

Cat. No.: HY-P10238: FAQs
Data Sheet Handling Instructions

Molarity Calculator

MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells.

For research use only. We do not sell to patients.

MYBMIM Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells^[1].

In Vitro

MYBMIM (10-20 μM) inhibits proliferation (6 days) and induces apoptosis (48 h) in acute myeloid leukemia cells by downregulating anti-apoptotic Bcl2 gene expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MOLM-13, MV-411, ML2, and HL60
Concentration:	10-20 μM
Incubation Time:	6 days
Result:	Inhibited cell viability.

Apoptosis Analysis^[1]

Cell Line:	MV-411
Concentration:	20 μM
Incubation Time:	4 h
Result:	Induced cell apoptosis.

Western Blot Analysis^[1]

Cell Line:	MOLM-13, MV-411, ML2, and HL60
Concentration:	10-20 μM
Incubation Time:	6 h
Result:	Downregulated levels of Bcl2

In Vivo

MYBMIM (25 mg/kg, ip, twice a day for 14 days) impedes human leukemia progression in mouse xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AML-MLL- leukemia xenograft mice model^[1]
Dosage:	25 mg/kg
Administration:	ip, twice a day for 14 days
Result:	Delayed leukemia progression and extended survival.

Molecular Weight

3884.57

Formula

C₁₆₆H₂₉₆N₆₀O₄₅S

Unlabeled CAS

Sequence

Ac-d-{Lys-Leu-Glu-Asn-Glu-Thr-Ser-Met-Leu-Leu-Leu-Glu-Leu-Glu-Lys-Ile-Arg-Lys-Gly-Gly-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Tyr}-NH2

Sequence Shortening

Ac-d-{KLENETSMLLLELEKIRKGG-RRRQRRKKRGY}-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ramaswamy K, et al., Peptidomimetic blockade of MYB in acute myeloid leukemia. Nat Commun. 2018 Jan 9;9(1):110. [Content Brief]

MYBMIM Related Classifications

Peptides

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MYBMIMApoptosisMOLM-13MV-411ML2HL60Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks