Myt1 - myelin transcription factor 1 Gene

Also Known as Nzf2; Nzf2a; Nzf2b; Nztf2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17932

Summary

This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Myt1 Products (4)

mRNA Protein Name
NM_001171615.1 NP_001165086.1 myelin transcription factor 1 isoform 3
NM_001171616.1 NP_001165087.1 myelin transcription factor 1 isoform 2
NM_001171680.1 NP_001165151.1 myelin transcription factor 1 isoform 4
NM_008665.4 NP_032691.2 myelin transcription factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17442045 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17442045 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17442045 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15935060 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within diaphragm development IMP
IMP: Inferred from mutant phenotype
17928203 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
17928203 MGI
acts upstream of or within intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
17928203 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17928203 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17928203 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17442045 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17928203 MGI
acts upstream of or within regulation of hormone metabolic process IMP
IMP: Inferred from mutant phenotype
17928203 MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
17928203 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9373037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin transcription factor 1

  • NZF-2

  • neural zinc finger factor 2

  • neural zinc finger transcription factor 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-183118 CID-078 / Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13925 PD0166285 99.46% Unkown
HY-122113 PD173952 99.58% Unkown
HY-145817 (Rac)-lunresertib Inhibitor 99.72% Unkown
HY-145664 Myt1-IN-1 Inhibitor 98.97% Unkown
HY-145666 Myt1-IN-3 Inhibitor 99.14% Unkown
HY-145817B (R)-lunresertib Inhibitor 99.72% Unkown
HY-145665 Myt1-IN-2 Inhibitor / Unkown
HY-13925A PD0166285 dihydrochloride / Unkown
HY-157443 Myt1-IN-4 Inhibitor / Unkown
HY-RS08973 MYT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08974 MYT1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10605 PKMYT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162988 Myt1-IN-5 Inhibitor / Unkown
HY-176853 Myt1-IN-6 Inhibitor / Unkown
HY-188057 Sirusertib Inhibitor / Unkown
HY-RS16738 Pkmyt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19620 Myt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21661 Myt1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26115 Myt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28179 Myt1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myt1 NCBI NCBI:4661