Nedd4 - neural precursor cell expressed, developmentally down-regulated 4 Gene

Also Known as Gm7265; Nedd4a; Nedd4-1; EG639396; KIAA0093; E430025J12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17999

Summary

Enables several functions, including ionotropic glutamate receptor binding activity; protein phosphorylated amino acid binding activity; and Sodium Channel Inhibitor activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including cellular protein metabolic process; circulatory system development; and neuromuscular junction development. Located in several cellular components, including cytosol; dendritic spine; and glutamatergic synapse. Part of ubiquitin Ligase complex. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4 Products (2)

mRNA Protein Name
NM_001357998.1 NP_001344927.1 E3 ubiquitin-protein ligase NEDD4 isoform 2
NM_010890.4 NP_035020.2 E3 ubiquitin-protein ligase NEDD4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IDA
IDA: Inferred from direct assay
25505317 MGI
enables phosphoserine residue binding IDA
IDA: Inferred from direct assay
10037602 MGI
enables phosphothreonine residue binding IDA
IDA: Inferred from direct assay
10037602 MGI
enables proline-rich region binding IPI
IPI: Inferred from physical interaction
9305852 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10446181 MGI
enables sodium channel inhibitor activity IDA
IDA: Inferred from direct assay
10212229 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
9182527 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
18931680 MGI
acts upstream of or within adaptive immune response IMP
IMP: Inferred from mutant phenotype
18931680 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
20026598 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
20026598 MGI
acts upstream of or within endocardial cushion development IGI
IGI: Inferred from genetic interaction
20026598 MGI
acts upstream of or within endocardial cushion development IMP
IMP: Inferred from mutant phenotype
20026598 MGI
acts upstream of establishment of localization in cell IDA
IDA: Inferred from direct assay
10212229 MGI
acts upstream of or within negative regulation of sodium ion transport IDA
IDA: Inferred from direct assay
10212229 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20026598 MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
15060076 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
19345204 MGI
acts upstream of or within outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
20026598 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
20026598 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
11748237 MGI
acts upstream of or within protein monoubiquitination IDA
IDA: Inferred from direct assay
21920314 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
9182527 MGI
involved in regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
20159449 MGI
acts upstream of or within regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
19345204 MGI
acts upstream of sodium ion transport IDA
IDA: Inferred from direct assay
10212229 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
18931680 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14973438 MGI
located in cytosol IDA
IDA: Inferred from direct assay
9182527 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25505317 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25505317 MGI
located in membrane IDA
IDA: Inferred from direct assay
14973438 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
25505317 MGI
is active in postsynaptic cytosol IMP
IMP: Inferred from mutant phenotype
25505317 MGI
part of ubiquitin ligase complex IPI
IPI: Inferred from physical interaction
11042109 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NEDD4

  • HECT-type E3 ubiquitin transferase NEDD4

  • neural precursor cell expressed developmentally down-regulated protein 4

  • neural precursor cell expressed, developmentally down-regulated gene 4a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110204 Heclin Inhibitor 98.00% Unkown
HY-134417 NSC2805 Inhibitor 99.42% Unkown
HY-N10159 1-Benzyl-I3C Inhibitor 99.68% Unkown
HY-162809 XMU-MP-9 99.12% Unkown
HY-110174 NAB2 Degrader 99.69% Unkown
HY-153178 HECT E3-IN-1 Inhibitor 99.44% Unkown
HY-179570 XMU-MP-10 Inhibitor 98.10% Unkown
HY-122046 Amb123203 98.87% Unkown
HY-RS09180 NEDD4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09179 NEDD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124791 MMRi6 99.70% Unkown
HY-RS17116 Nedd4l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17232 Nedd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23561 Nedd4l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23685 Nedd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nedd4 NCBI NCBI:4734