DPEP1 - dipeptidase 1 Gene

Also Known as MDP; RDP; MBD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1800

About DPEP1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,613,308-89,641,540 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues.

Summary

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and Other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]

DPEP1 Products (8)

mRNA Protein Name
NM_001128141.3 NP_001121613.1 dipeptidase 1 isoform a precursor
NM_001389466.1 NP_001376395.1 dipeptidase 1 isoform a precursor
NM_001389467.1 NP_001376396.1 dipeptidase 1 isoform a precursor
NM_001389468.1 NP_001376397.1 dipeptidase 1 isoform a precursor
NM_001389469.1 NP_001376398.1 dipeptidase 1 isoform a precursor
NM_001389470.1 NP_001376399.1 dipeptidase 1 isoform b precursor
NM_001389471.1 NP_001376400.1 dipeptidase 1 isoform b precursor
NM_004413.4 NP_004404.1 dipeptidase 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-lactamase activity IDA
IDA: Inferred from direct assay
6334084 GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20435919 GOA
enables dipeptidase activity IDA
IDA: Inferred from direct assay
32325220 GOA
enables metallodipeptidase activity IDA
IDA: Inferred from direct assay
12144777 GOA
enables modified amino acid binding IDA
IDA: Inferred from direct assay
20031578 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
12144777 GOA
Biological Process GO Annotation Evidence References Source
involved in antibiotic metabolic process IDA
IDA: Inferred from direct assay
6334084 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
20435919 GOA
involved in homocysteine metabolic process IDA
IDA: Inferred from direct assay
20031578 GOA
involved in leukotriene D4 catabolic process IDA
IDA: Inferred from direct assay
32325220 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20435919 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20824289 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20435919 GOA
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
20824289 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12144777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPEP1 Protein Structure

Peptidase_M19

Peptidase_M19: Membrane dipeptidase (Peptidase family M19) (26 - 351)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

dipeptidase 1

  • beta-lactamase

DPEP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPEP1 P16444 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
DPEP1 P16444 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
DPEP1 P16444 KIFBP Homo sapiens Q96EK5
Pull Down
16189514
Intra
DPEP1 P16444 KIFBP Homo sapiens Q96EK5
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPEP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70003 DPEP1 Protein, Human (HEK293, His) P16444 (D17-S385) ≥ 95%, as determined by reducing SDS-PAGE.

DPEP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81486 DPEP1/MDP Antibody (YA1231) IHC-P Human
HY-P81486A DPEP1/MDP Antibody (YA1231)(PBS only) IHC-P Human
HY-P81557 DPEP1/MDP Antibody (YA1302) IHC-P Human, Rat

Related Diseases

Diseases Alias
Blau Syndrome

  • Arthrocutaneouveal Granulomatosis

  • Jabs Syndrome

  • BLAUS

  • Sarcoidosis, Early-Onset

  • Acug

  • Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial

  • Eos

  • Granulomatosis, Familial Juvenile Systemic

  • Granulomatosis, Familial, Blau Type

  • Familial Juvenile Systemic Granulomatosis

  • Early Onset Sarcoidosis

  • Synovitis Granulomatous With Uveitis And Cranial Neuropathies

  • Early-Onset Sarcoidosis

  • Familial Granulomatosis, Blau Type

  • Pediatric Granulomatous Arthritis

  • Familial Granulomatosis Blau Type

  • Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis

  • Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Carbapenem Allergy
Bacterial Infectious Disease

  • Bacterial Infections

  • Bacterial Infection Nos

  • Disease Caused By Bacteria

  • Bacterial Disease Or Disorder
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11879 LSALT peptide Inhibitor / Unkown
HY-RS03947 DPEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19187 Dpep1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25675 Dpep1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPEP1 VGNC VGNC:61593
Canis familiaris DPEP1 VGNC VGNC:49599
Macaca mulatta DPEP1 VGNC VGNC:71972
Mus musculus DPEP1 MGD MGI:94917
Bos taurus DPEP1 VGNC VGNC:49143
Rattus norvegicus DPEP1 RGD RGD:620324
Others DPEP1 NCBI