DPEP1 - dipeptidase 1 Gene

Homo sapiens

Also known as MDP; RDP; MBD1

Gene ID: 1800 | Gene type: protein coding

About DPEP1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,613,308-89,641,540 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues.

Summary

The protein encoded by this gene is a kidney membrane Enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]

DPEP1 Products(8)

mRNA	Protein	Name
NM_001128141.3	NP_001121613.1	dipeptidase 1 isoform a precursor
NM_001389466.1	NP_001376395.1	dipeptidase 1 isoform a precursor
NM_001389467.1	NP_001376396.1	dipeptidase 1 isoform a precursor
NM_001389468.1	NP_001376397.1	dipeptidase 1 isoform a precursor
NM_001389469.1	NP_001376398.1	dipeptidase 1 isoform a precursor
NM_001389470.1	NP_001376399.1	dipeptidase 1 isoform b precursor
NM_001389471.1	NP_001376400.1	dipeptidase 1 isoform b precursor
NM_004413.4	NP_004404.1	dipeptidase 1 isoform a precursor

DPEP1 Protein Structure

Peptidase_M19

0
100
200
300
411 a.a.

Protein Preferred Names

Protein Names

dipeptidase 1

beta-lactamase

Recombinant DPEP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70003	DPEP1 Protein, Human (HEK293, His)	P16444 (D17-S385)	≥95%

Related Diseases

Diseases

Alias

Blau Syndrome

Arthrocutaneouveal Granulomatosis	Jabs Syndrome
BLAUS	Sarcoidosis, Early-Onset
Acug	Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial
Eos	Granulomatosis, Familial Juvenile Systemic
Granulomatosis, Familial, Blau Type	Familial Juvenile Systemic Granulomatosis
Early Onset Sarcoidosis	Synovitis Granulomatous With Uveitis And Cranial Neuropathies
Early-Onset Sarcoidosis	Familial Granulomatosis, Blau Type
Pediatric Granulomatous Arthritis	Familial Granulomatosis Blau Type
Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis	Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies

Carbapenem Allergy

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03947	DPEP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DPEP1	VGNC	VGNC:61593
Canis familiaris	DPEP1	VGNC	VGNC:49599
Macaca mulatta	DPEP1	VGNC	VGNC:71972
Mus musculus	DPEP1	MGD	MGI:94917
Bos taurus	DPEP1	VGNC	VGNC:49143
Rattus norvegicus	DPEP1	RGD	RGD:620324
Others	DPEP1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.