Nf1 - neurofibromin 1 Gene

Also Known as Dsk9; Nf-1; Mhdadsk9; E030030H24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18015

Summary

Enables GTPase activator activity. Involved in negative regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; modulation of chemical synaptic transmission; and nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Used to study juvenile myelomonocytic leukemia and neurofibromatosis. Human ortholog(s) of this gene implicated in autistic disorder; hematologic Cancer (multiple); nervous system Cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nf1 Products (1)

mRNA Protein Name
NM_010897.2 NP_035027.1 neurofibromin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IGI
IGI: Inferred from genetic interaction
15665300 MGI
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
8563750 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16405917 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16644864 MGI
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
14724565 MGI
acts upstream of Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of Ras protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within Ras protein signal transduction IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
11246230 MGI
acts upstream of or within Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
8563750 MGI
acts upstream of or within Schwann cell development IMP
IMP: Inferred from mutant phenotype
9001241 MGI
acts upstream of Schwann cell migration IGI
IGI: Inferred from genetic interaction
14724565 MGI
acts upstream of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
14724565 MGI
acts upstream of Schwann cell proliferation IGI
IGI: Inferred from genetic interaction
9001241 MGI
acts upstream of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
9001241 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
16405917 MGI
acts upstream of or within adrenal gland development IMP
IMP: Inferred from mutant phenotype
16906226 MGI
acts upstream of or within amygdala development IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of angiogenesis IGI
IGI: Inferred from genetic interaction
16648142 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
15944386 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9878702 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
10419687 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of or within cell communication IMP
IMP: Inferred from mutant phenotype
10442636 MGI
acts upstream of cell migration IGI
IGI: Inferred from genetic interaction
14724565 MGI
acts upstream of cell migration IMP
IMP: Inferred from mutant phenotype
14724565 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
9001241 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
8563750 MGI
acts upstream of or within cellular response to heat IDA
IDA: Inferred from direct assay
20661302 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
11297510 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
10383727 MGI
acts upstream of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16288202 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
16835260 MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
15039234 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: Inferred from genetic interaction
15039234 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
15039234 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
10383727 MGI
acts upstream of or within forebrain astrocyte development IMP
IMP: Inferred from mutant phenotype
15944386 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
11297510 MGI
acts upstream of or within gamma-aminobutyric acid secretion, neurotransmission IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of glial cell proliferation IGI
IGI: Inferred from genetic interaction
10973261 MGI
acts upstream of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
10442636 MGI
acts upstream of or within glutamate secretion, neurotransmission IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within hair follicle maturation IMP
IMP: Inferred from mutant phenotype
25340873 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
7920653 MGI
acts upstream of leukocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17053831 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of or within long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
16271875 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
16271875 MGI
acts upstream of mast cell apoptotic process IGI
IGI: Inferred from genetic interaction
15039234 MGI
acts upstream of mast cell proliferation IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
10586246 MGI
acts upstream of myeloid cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17053831 MGI
acts upstream of myeloid leukocyte migration IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within negative regulation of MAP kinase activity IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
11297510 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16644864 MGI
acts upstream of or within negative regulation of Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
11246230 MGI
acts upstream of or within negative regulation of Schwann cell migration IGI
IGI: Inferred from genetic interaction
14724565 MGI
acts upstream of or within negative regulation of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
14724565 MGI
acts upstream of or within negative regulation of Schwann cell proliferation IGI
IGI: Inferred from genetic interaction
9001241 MGI
acts upstream of or within negative regulation of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
9001241 MGI
acts upstream of or within negative regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
16648142 MGI
acts upstream of or within negative regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9878702 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10591652 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
8563750 MGI
acts upstream of or within negative regulation of cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16288202 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
10383727 MGI
involved in negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20154697 MGI
acts upstream of or within negative regulation of glial cell proliferation IGI
IGI: Inferred from genetic interaction
10973261 MGI
acts upstream of or within negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
10442636 MGI
acts upstream of or within negative regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within negative regulation of mast cell proliferation IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within negative regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of or within negative regulation of neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
16298082 MGI
acts upstream of or within negative regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
16298082 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15944386 MGI
acts upstream of or within negative regulation of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within negative regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
12469121 MGI
acts upstream of or within negative regulation of protein kinase activity IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
16835260 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10591653 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
10419687 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
7671302 MGI
acts upstream of neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
16298082 MGI
acts upstream of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
16298082 MGI
acts upstream of or within observational learning IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15944386 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
16893911 MGI
acts upstream of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
10419687 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
14724565 MGI
acts upstream of or within pigmentation IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
10594763 MGI
acts upstream of or within positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
8563750 MGI
acts upstream of or within positive regulation of adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
11788835 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15944386 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
15039234 MGI
acts upstream of or within positive regulation of leukocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17053831 MGI
acts upstream of or within positive regulation of mast cell apoptotic process IGI
IGI: Inferred from genetic interaction
15039234 MGI
acts upstream of or within positive regulation of myeloid cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17053831 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
7671302 MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
12469121 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
16271875 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
16271875 MGI
acts upstream of or within regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
16288202 MGI
acts upstream of or within regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
17053831 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10678181 MGI
acts upstream of or within regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
16405917 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within regulation of glial cell differentiation IMP
IMP: Inferred from mutant phenotype
12904481 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IGI
IGI: Inferred from genetic interaction
11793011 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11793011 MGI
acts upstream of or within regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
25242307 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
22105171 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
22105171 MGI
acts upstream of or within regulation of synaptic transmission, GABAergic IGI
IGI: Inferred from genetic interaction
11793011 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
16288202 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of or within smooth muscle tissue development IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of or within spinal cord development IMP
IMP: Inferred from mutant phenotype
16906226 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10591653 MGI
acts upstream of or within sympathetic nervous system development IMP
IMP: Inferred from mutant phenotype
7926784 MGI
acts upstream of vascular associated smooth muscle cell migration IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of vascular associated smooth muscle cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
9054942 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
11793011 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
10383727 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15133494 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22105171 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22105171 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurofibromin

  • neurofibromatosis 1

  • neurofibromatosis-related protein NF-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-W273690 Pentifylline Inhibitor 99.23% Phase 4
HY-158115 NST-628 Inhibitor 99.35% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156872 MTX-216 / Unkown
HY-RS09233 NF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113821 1-Naphthyl phosphate potassium salt Inhibitor 99.86% Unkown
HY-120614 BMS-186511 Inhibitor / Unkown
HY-RS17398 Nf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23853 Nf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nf1 NCBI NCBI:4763