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Cat. No.: HY-187882

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Nuvrumetinib

Name: Nuvrumetinib
Brand: MedChemExpress
SKU: HY-187882
Availability: PreOrder

(Synonyms: PAS-004)

Nuvrumetinib (PAS-004) is a macrocyclic MEK inhibitor. Nuvrumetinib functionally inhibits MEK1/2, thereby suppressing pERK in tumors. Nuvrumetinib inhibits the proliferation of NRAS-mutant cancer cells. Nuvrumetinib can be used in studies related to NRAS^G12C-mutant solid tumors, neurofibromatosis type 1 (NF1), RASopathies and laminopathies.

For research use only. We do not sell to patients.

CAS No.: 3079099-31-0
Formula: C₁₉H₁₈F₃IN₂O₅S
Molecular Weight:570.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Nuvrumetinib Chemical Structure

CAS No.: 3079099-31-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target

^[1]

MEK1

MEK2

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In Vitro

Nuvrumetinib (48 h) inhibits the proliferation of NRAS^G12X-mutated cancer cell lines in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3079099-31-0
Molecular Weight 570.32
Formula C₁₉H₁₈F₃IN₂O₅S
SMILES

O=S1(C2(C[C@H]([C@H](COC3=CC(F)=C(F)C(NC4=C(C=C(C=C4)I)F)=C3N1)O)O)CC2)=O
Synonyms

PAS-004
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. WHO Drug Information, Vol. 40, No. 2, 2026

[2]. Mathew LAZARUS, et al. Solid forms comprising (5r,6s)-10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1h-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane] 2,2-dioxide, and compositions comprising and methods of using the same. WO2025147497A1. 2026-07-05.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Nuvrumetinib

All MEK Isoforms

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IC50 & Target

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