Ngfr - nerve growth factor receptor (TNFR superfamily, member 16) Gene

Also Known as p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18053

Summary

Enables death receptor activity; nerve growth factor binding activity; and small GTPase binding activity. Involved in several processes, including cellular glucose homeostasis; circadian regulation of gene expression; and dorsal aorta development. Acts upstream of or within several processes, including hair follicle morphogenesis; nervous system development; and regulation of signal transduction. Located in several cellular components, including cell surface; cell-cell junction; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ngfr Products (1)

mRNA Protein Name
NM_033217.3 NP_150086.2 tumor necrosis factor receptor superfamily member 16 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables death receptor activity IDA
IDA: Inferred from direct assay
10764727 MGI
enables nerve growth factor binding IDA
IDA: Inferred from direct assay
1317267 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10545116 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
22460790 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
11978834 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
11978834 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23785138 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
23785138 MGI
acts upstream of or within detection of temperature stimulus IMP
IMP: Inferred from mutant phenotype
1317267 MGI
involved in dorsal aorta development IMP
IMP: Inferred from mutant phenotype
11559852 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10588868 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
10588868 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
22460790 MGI
acts upstream of hair follicle development IMP
IMP: Inferred from mutant phenotype
10588868 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
10588868 MGI
involved in intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
22460790 MGI
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
22460790 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10588868 MGI
acts upstream of or within negative regulation of hair follicle development IMP
IMP: Inferred from mutant phenotype
10588868 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
1317267 MGI
acts upstream of odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
9268129 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10764727 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
10588868 MGI
acts upstream of or within positive regulation of odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
9268129 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
31514753 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
31514753 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
10588868 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
1317267 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10021336 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
21300049 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19295126 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
31514753 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
31514753 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10536054 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
24069373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 16

  • NGF receptor

  • low affinity neurotrophin receptor p75NTR

  • low-affinity nerve growth factor receptor

  • p75 neurotrophin receptor

Recombinant Ngfr Proteins

Cat. No. Product Name Accession Purity
HY-P77100 NGFR Protein, Mouse (HEK293, Fc) Q9Z0W1 (M1-N253) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77101 NGFR Protein, Mouse (HEK293, His) Q9Z0W1 (K32-N253) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111163 NSC49652 Inducer 98.74% Unkown
HY-RS09278 NGFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17166 Ngfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23616 Ngfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ngfr NCBI NCBI:4804