Nodal - nodal Gene

Also Known as Tg.413d

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18119

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]

Nodal Products (1)

mRNA Protein Name
NM_013611.5 NP_038639.2 nodal preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12052855 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
12052855 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anatomical structure formation involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
7924997 MGI
acts upstream of or within anterior/posterior axis specification IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16496285 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within axial mesodermal cell fate specification IMP
IMP: Inferred from mutant phenotype
14511481 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of cell differentiation IDA
IDA: Inferred from direct assay
11456449 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
12842913 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
15302604 MGI
acts upstream of or within cell migration involved in gastrulation IDA
IDA: Inferred from direct assay
15004567 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15004567 MGI
involved in determination of left/right asymmetry in lateral mesoderm IMP
IMP: Inferred from mutant phenotype
17507406 MGI
acts upstream of or within determination of left/right symmetry IDA
IDA: Inferred from direct assay
12642485 MGI
acts upstream of or within determination of left/right symmetry IGI
IGI: Inferred from genetic interaction
15466485 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within digestive system development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
11456449 MGI
acts upstream of or within embryonic process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
11456449 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification IMP
IMP: Inferred from mutant phenotype
14511481 MGI
acts upstream of or within floor plate morphogenesis IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within formation of anatomical boundary IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
14607953 MGI
acts upstream of germ cell development IMP
IMP: Inferred from mutant phenotype
23034635 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within heart looping IGI
IGI: Inferred from genetic interaction
16496285 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16678814 MGI
acts upstream of or within left lung morphogenesis IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within maternal placenta development IMP
IMP: Inferred from mutant phenotype
22378764 MGI
acts upstream of or within maternal process involved in parturition IMP
IMP: Inferred from mutant phenotype
22378764 MGI
acts upstream of or within mesendoderm development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within negative regulation of cell development IMP
IMP: Inferred from mutant phenotype
23034635 MGI
acts upstream of or within negative regulation of cell differentiation IDA
IDA: Inferred from direct assay
11456449 MGI
acts upstream of or within negative regulation of reproductive process IMP
IMP: Inferred from mutant phenotype
23034635 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11456449 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within neural fold formation IMP
IMP: Inferred from mutant phenotype
11311163 MGI
involved in nodal signaling pathway IMP
IMP: Inferred from mutant phenotype
12052855 MGI
acts upstream of or within polarity specification of proximal/distal axis IMP
IMP: Inferred from mutant phenotype
14511481 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21116837 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15004567 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17507406 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17568773 MGI
acts upstream of or within primitive streak formation IGI
IGI: Inferred from genetic interaction
21445260 MGI
acts upstream of or within regulation of gastrulation IGI
IGI: Inferred from genetic interaction
20040491 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: Inferred from direct assay
17936261 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
15505202 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
16678814 MGI
acts upstream of or within stem cell population maintenance IGI
IGI: Inferred from genetic interaction
15505202 MGI
acts upstream of or within tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
11311163 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14511481 MGI
acts upstream of or within trophectodermal cell differentiation IDA
IDA: Inferred from direct assay
11456449 MGI
acts upstream of or within trophectodermal cellular morphogenesis IMP
IMP: Inferred from mutant phenotype
11456449 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
11311163 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
12052855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nodal

Recombinant Nodal Proteins

Cat. No. Product Name Accession Purity
HY-P79080 Nodal Protein, Mouse P43021 (H245-L354) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0016 Dronedarone 99.93% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106577 Cibenzoline 95.08% Phase 4

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10432 A 83-01 Inhibitor 99.41% Unkown
HY-10432R A 83-01 (Standard) Inhibitor / Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-180334 S-312 Antagonist / Unkown
HY-RS09409 NODAL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123196 CVT-2759 Inhibitor / Unkown
HY-RS19222 Nodal Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25711 Nodal Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nodal NCBI NCBI:4838