Ntsr2 - neurotensin receptor 2 Gene

Also Known as NT2R; NTR2; NTRL; NT-R-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18217

About Ntsr2

Chromosome 12: 16,703,383-16,710,228 forward strand.GRCm39:CM001005.3

This gene has 5 transcripts (splice variants), 79 orthologues, 14 paralogues and is associated with 4 phenotypes. Biased expression in genital fat pad adult (RPKM 7.4), cortex adult (RPKM 64.8) and 5 other tissues.

Summary

Enables G protein-coupled Neurotensin Receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway and regulation of membrane potential. Located in membrane. Orthologous to human NTSR2 (Neurotensin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntsr2 Products (5)

mRNA Protein Name
NM_001361702.2 NP_001348631.1 neurotensin receptor type 2 isoform 2
NM_001361703.2 NP_001348632.1 neurotensin receptor type 2 isoform 3
NM_001412674.1 NP_001399603.1 neurotensin receptor type 2 isoform 4
NM_001412675.1 NP_001399604.1 neurotensin receptor type 2 isoform 5
NM_008747.3 NP_032773.2 neurotensin receptor type 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled neurotensin receptor activity IDA
IDA: Inferred from direct assay
8795617 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8795617 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
8795617 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
8795617 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntsr2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (32 - 368)

7tm_GPCRs

7tm_GPCRs: cd14964 (34 - 58)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 90)

7tm_GPCRs

7tm_GPCRs: cd14964 (108 - 130)

7tm_GPCRs

7tm_GPCRs: cd14964 (153 - 169)

7tm_GPCRs

7tm_GPCRs: cd14964 (203 - 226)

7tm_GPCRs

7tm_GPCRs: cd14964 (295 - 317)

7tm_GPCRs

7tm_GPCRs: cd14964 (336 - 361)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

neurotensin receptor type 2

  • low affinity neurotensin receptor

  • low-affinity levocabastine-sensitive neurotensin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11845 DOTA-NT-20.3-IPBA Modulator / Unkown
HY-RS09641 NTSR2 Human Pre-designed siRNA Set A / Unkown
HY-RS09642 Ntsr2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09643 Ntsr2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntsr2 NCBI NCBI:23620