Ocln - occludin Gene

Also Known as Ocl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18260

Summary

Predicted to enable protein domain specific binding activity. Involved in negative regulation of gene expression and tight junction organization. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and bicellular tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Apr 2022]

Ocln Products (5)

mRNA Protein Name
NM_001360536.1 NP_001347465.1 occludin isoform 1
NM_001360537.1 NP_001347466.1 occludin isoform 1
NM_001360538.1 NP_001347467.1 occludin isoform 1
NM_001360539.1 NP_001347468.1 occludin isoform 2
NM_008756.2 NP_032782.1 occludin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11782481 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21415414 MGI
involved in tight junction organization IMP
IMP: Inferred from mutant phenotype
30734065 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20089884 MGI
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
16520537 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
11025210 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12734665 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15528189 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11782481 MGI
located in tight junction IDA
IDA: Inferred from direct assay
23239027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

occludin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09743 OCLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22265 Ocln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28788 Ocln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ocln NCBI NCBI:100506658