Tnfrsf11b - tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Gene

Also Known as Opg; TR1; OCIF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18383

Summary

Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF Receptor Superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11b Products (2)

mRNA Protein Name
NM_001411506.1 NP_001398435.1 tumor necrosis factor receptor superfamily member 11B isoform 2
NM_008764.4 NP_032790.3 tumor necrosis factor receptor superfamily member 11B isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparan sulfate binding IDA
IDA: Inferred from direct assay
29415886 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23039992 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within negative regulation of odontogenesis of dentin-containing tooth IDA
IDA: Inferred from direct assay
14981127 MGI
acts upstream of or within negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
29415886 MGI
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
9168977 MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
29415886 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
9108485 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 11B

  • osteoclastogenesis inhibitory factor

  • osteoprotegerin

Recombinant Tnfrsf11b Proteins

Cat. No. Product Name Accession Purity
HY-P71017 TNFRSF11B/OPG Protein, Mouse (HEK293, His) O08712 (E22-L401) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14802 TNFRSF11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17571 Tnfrsf11b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24031 Tnfrsf11b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf11b NCBI NCBI:4982