2. Gene
  3. P2rx7 - purinergic receptor P2X, ligand-gated ion channel, 7 Gene

P2rx7 - purinergic receptor P2X, ligand-gated ion channel, 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as P2X7R; P2X(7)

Gene ID: 18439 | Gene type: protein coding

About P2rx7

Chromosome 5: 122,781,974-122,829,495 forward strand.GRCm39:CM000998.3

This gene has 8 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 27 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in negative regulation of cell volume and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is integral component of plasma membrane. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2rx7 Products(5)

mRNA Protein Name
NM_011027.4 NP_035157.2 P2X purinoceptor 7 isoform a
NM_001284402.2 NP_001271331.1 P2X purinoceptor 7 isoform e
NM_001038839.3 NP_001033928.1 P2X purinoceptor 7 isoform c
NM_001038887.2 NP_001033976.1 P2X purinoceptor 7 isoform d
NM_001038845.3 NP_001033934.1 P2X purinoceptor 7 isoform b

P2rx7 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (10 - 389)

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  • 595 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 7

ATP receptor

P2X7 purinoceptor

P2X7 receptor

P2Z receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09911 P2RX7 Human Pre-designed siRNA Set A / Unkown
HY-RS09912 P2rx7 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09913 P2RX7 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx7 NCBI NCBI:5027