P2rx7 - purinergic receptor P2X, ligand-gated ion channel, 7 Gene

Also Known as P2X7R; P2X(7)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18439

About P2rx7

Chromosome 5: 122,781,974-122,829,495 forward strand.GRCm39:CM000998.3

This gene has 8 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 27 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in negative regulation of cell volume and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is integral component of plasma membrane. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2rx7 Products (5)

mRNA Protein Name
NM_011027.4 NP_035157.2 P2X purinoceptor 7 isoform a
NM_001284402.2 NP_001271331.1 P2X purinoceptor 7 isoform e
NM_001038839.3 NP_001033928.1 P2X purinoceptor 7 isoform c
NM_001038887.2 NP_001033976.1 P2X purinoceptor 7 isoform d
NM_001038845.3 NP_001033934.1 P2X purinoceptor 7 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
12677010 MGI
enables channel activity IMP
IMP: Inferred from mutant phenotype
18519738 MGI
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
12677010 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15713258 MGI
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
11489964 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15331634 MGI
enables signaling receptor activity IMP
IMP: Inferred from mutant phenotype
12677010 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15937334 MGI
acts upstream of or within NAD transport IMP
IMP: Inferred from mutant phenotype
17803959 MGI
acts upstream of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16325464 MGI
acts upstream of or within T cell homeostasis IMP
IMP: Inferred from mutant phenotype
16116196 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
14761980 MGI
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
15914561 MGI
acts upstream of or within bleb assembly IMP
IMP: Inferred from mutant phenotype
17135244 MGI
involved in bleb assembly IMP
IMP: Inferred from mutant phenotype
25651887 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
12370338 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
12055263 MGI
acts upstream of or within cell volume homeostasis IDA
IDA: Inferred from direct assay
18097031 MGI
acts upstream of or within cellular response to dsRNA IMP
IMP: Inferred from mutant phenotype
24114535 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23479225 MGI
acts upstream of or within cellular response to stimulus IMP
IMP: Inferred from mutant phenotype
18082965 MGI
acts upstream of or within ceramide biosynthetic process IDA
IDA: Inferred from direct assay
16325464 MGI
acts upstream of or within collagen metabolic process IMP
IMP: Inferred from mutant phenotype
16969386 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
11544318 MGI
acts upstream of establishment of localization in cell IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
18097031 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
16269410 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12370338 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17286969 MGI
acts upstream of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
15640761 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
18519738 MGI
acts upstream of glutamate secretion IMP
IMP: Inferred from mutant phenotype
15640761 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
16969386 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
12055263 MGI
acts upstream of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16493071 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of or within membrane protein ectodomain proteolysis IMP
IMP: Inferred from mutant phenotype
17286969 MGI
acts upstream of mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
16198349 MGI
acts upstream of or within mitochondrion organization IDA
IDA: Inferred from direct assay
16325464 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
12677010 MGI
acts upstream of or within negative regulation of MAPK cascade IDA
IDA: Inferred from direct assay
11489964 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
12677010 MGI
involved in negative regulation of cell volume IMP
IMP: Inferred from mutant phenotype
25651887 MGI
acts upstream of or within phagolysosome assembly IMP
IMP: Inferred from mutant phenotype
11544318 MGI
acts upstream of or within phospholipid transfer to membrane IMP
IMP: Inferred from mutant phenotype
12370338 MGI
acts upstream of or within phospholipid translocation IDA
IDA: Inferred from direct assay
18097031 MGI
acts upstream of or within plasma membrane organization IDA
IDA: Inferred from direct assay
18097031 MGI
acts upstream of or within pore complex assembly IMP
IMP: Inferred from mutant phenotype
12370338 MGI
acts upstream of or within positive regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
17306762 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15937334 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16325464 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
14761980 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16969386 MGI
acts upstream of or within positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
12677010 MGI
acts upstream of or within positive regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
14761980 MGI
acts upstream of or within positive regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
15640761 MGI
acts upstream of or within positive regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
15640761 MGI
acts upstream of or within positive regulation of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16493071 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of or within positive regulation of mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
16198349 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
16269410 MGI
acts upstream of or within positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
16269410 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15937334 MGI
acts upstream of or within positive regulation of protein secretion IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within programmed cell death IDA
IDA: Inferred from direct assay
16116196 MGI
acts upstream of or within programmed cell death IMP
IMP: Inferred from mutant phenotype
14761980 MGI
acts upstream of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
16269410 MGI
acts upstream of or within protein catabolic process IDA
IDA: Inferred from direct assay
11489964 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17306762 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of protein secretion IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
17448897 MGI
acts upstream of or within release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
18082965 MGI
acts upstream of or within response to ATP IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
11016935 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
10395640 MGI
acts upstream of or within response to calcium ion IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within response to calcium ion IMP
IMP: Inferred from mutant phenotype
15978588 MGI
acts upstream of or within response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
15640761 MGI
acts upstream of or within response to fluid shear stress IMP
IMP: Inferred from mutant phenotype
16269410 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
12055263 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
16269410 MGI
acts upstream of or within response to organic cyclic compound IDA
IDA: Inferred from direct assay
15240711 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
18082965 MGI
acts upstream of or within response to zinc ion IMP
IMP: Inferred from mutant phenotype
15978588 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
15777864 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
18519738 MGI
acts upstream of or within synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
15713258 MGI
acts upstream of or within vesicle budding from membrane IMP
IMP: Inferred from mutant phenotype
15905573 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
15331634 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17286969 MGI
located in membrane IDA
IDA: Inferred from direct assay
15713258 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
15713258 MGI
is active in neuromuscular junction IPI
IPI: Inferred from physical interaction
15713258 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
15964665 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15331634 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
12677010 MGI
located in synapse IDA
IDA: Inferred from direct assay
18082965 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx7 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (10 - 389)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 7

  • ATP receptor

  • P2X7 purinoceptor

  • P2X7 receptor

  • P2Z receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0298 Clemastine 99.26% Yes

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09912 P2rx7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09911 P2RX7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09913 P2RX7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx7 NCBI NCBI:5027