Pgk1 - phosphoglycerate kinase 1 Gene

Also Known as Pgk-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18655

Summary

The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]

Pgk1 Products (1)

mRNA Protein Name
NM_008828.3 NP_032854.2 phosphoglycerate kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoglycerate kinase activity IDA
IDA: Inferred from direct assay
943046 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
27782176 MGI
Biological Process GO Annotation Evidence References Source
involved in canonical glycolysis IGI
IGI: Inferred from genetic interaction
30174313 MGI
involved in gluconeogenesis IGI
IGI: Inferred from genetic interaction
19643083 MGI
acts upstream of or within glycolytic process IDA
IDA: Inferred from direct assay
15665293 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
4262895 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphoglycerate kinase 1

Recombinant Pgk1 Proteins

Cat. No. Product Name Accession Purity
HY-P74634 PGK1 Protein, Mouse (sf9, His) P09411 (M1-V417) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W195984 Z57346765 99.85% Unkown
HY-178761 PGK1-IN-1 Inhibitor 99.78% Unkown
HY-N8540 Ilicicolin H Inhibitor 96.7% Unkown
HY-178989 PGK1-IN-2 Inhibitor / Unkown
HY-177944 DC-PGKI Inhibitor / Unkown
HY-184191 PGK1-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pgk1 NCBI NCBI:5230