Pip5k1c - phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Gene

Also Known as Pip5kIgamma

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18717

Summary

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and talin binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle endocytosis. Acts upstream of or within axonogenesis; phosphatidylinositol biosynthetic process; and platelet aggregation. Located in cytosol and postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pip5k1c Products (4)

mRNA	Protein	Name
NM_001146687.2	NP_001140159.1	phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2
NM_001293646.1	NP_001280575.1	phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 3
NM_001293647.1	NP_001280576.1	phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 4
NM_008844.3	NP_032870.2	phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA IDA: Inferred from direct assay	9535851	MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IMP IMP: Inferred from mutant phenotype	20622009	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17290217	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	14741049	MGI
acts upstream of or within phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	20622009	MGI
acts upstream of or within phosphatidylinositol biosynthetic process	IMP IMP: Inferred from mutant phenotype	20622009	MGI
acts upstream of or within phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	9535851	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	23372168	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	22243752	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	22243752	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	22243752	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	15386003	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	15386003	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	20622009	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22243752	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	22243752	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22243752	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22243752	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	22243752	MGI
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	22243752	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	PIP5K1-gamma phosphatidylinositol 4-phosphate 5-kinase type I gamma ptdIns(4)P-5-kinase 1 gamma

Pip5k1c Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pip5k1c	O70161	Ap2b1	Mus musculus	Q9DBG3-2	Pull Down	17290217
Intra	Pip5k1c	O70161	Ap2b1	Mus musculus	Q9DBG3-2	Anti Bait CoIP	17290217
Intra	Pip5k1c	O70161	Ap2b1	Mus musculus	Q9DBG3-2	Anti Tag CoIP	17290217
Intra	Pip5k1c	O70161	Ap2b1	Mus musculus	Q9DBG3-1	Protein Kinase Assay	17290217
Intra	Pip5k1c	O70161	Ap2b1	Mus musculus	Q9DBG3-1	Anti Tag CoIP	17290217

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110150	UNC3230	Inhibitor	99.39%	Unkown
HY-163476	PIP5K1C-IN-1	Inhibitor	98.71%	Unkown
HY-163943	UNI418	Inhibitor	99.61%	Unkown
HY-163477	PIP5K1C-IN-2	Inhibitor	/	Unkown
HY-E70633	PIP5K1C Recombinant Human Active Lipid Kinase		/	Unkown
HY-RS10568	PIP5K1C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19283	Pip5k1c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25773	Pip5k1c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pip5k1c	NCBI	NCBI:23396