Serpine1 - serine (or cysteine) peptidase inhibitor, clade E, member 1 Gene

Also Known as PAI1; PAI-1; Planh1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18787

About Serpine1

Chromosome 5: 137,090,358-137,101,122 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 187 orthologues, 63 paralogues and is associated with 44 phenotypes. Biased expression in placenta adult (RPKM 8.4), liver E18 (RPKM 11.4) and 3 other tissues.

Summary

Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (Serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpine1 Products (1)

mRNA Protein Name
NM_008871.2 NP_032897.2 plasminogen activator inhibitor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8939962 MGI
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
15328353 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of angiogenesis IMP
IMP: Inferred from mutant phenotype
21119013 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
21829547 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
17032919 MGI
involved in negative regulation of plasminogen activation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
involved in negative regulation of vascular wound healing IMP
IMP: Inferred from mutant phenotype
9386191 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
21119013 MGI
acts upstream of or within positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21119013 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
18835034 MGI
acts upstream of or within regulation of angiogenesis IDA
IDA: Inferred from direct assay
11818362 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18258607 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Serpine1 Protein Structure

serpin

serpin: cl38926 (28 - 401)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

plasminogen activator inhibitor 1

  • PAI

  • Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)

  • endothelial plasminogen activator inhibitor

  • nexin, plasminogen activator inhibitor type 1

  • plasminogen activator inhibitor, type I

  • serine (or cysteine) proteinase inhibitor, clade E, member 1

  • serpin E1

Recombinant Serpine1 Proteins

Cat. No. Product Name Accession Purity
HY-P71133 Serpin E1 Protein, Mouse (HEK293, His) G5E899 (T23-P402) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14759 Aleplasinin 99.59% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12720 SERPINE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183583 HIF-2α-IN-18 Inhibitor / Unkown
HY-RS12721 Serpine1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12722 Serpine1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990504 Anti-SERPINE1 Antibody Inhibitor ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpine1 NCBI NCBI:5054