LPAR1 - lysophosphatidic acid receptor 1 Gene

Also Known as EDG2; LPA1; VZG1; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1902

About LPAR1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:110,873,263-111,038,998 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 14.7), placenta (RPKM 8.1) and 22 other tissues.

Summary

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

LPAR1 Products (77)

mRNA Protein Name
NM_001351404.2 NP_001338333.1 lysophosphatidic acid receptor 1 isoform a
NM_001387507.1 NP_001374436.1 lysophosphatidic acid receptor 1 isoform a
NM_001351420.2 NP_001338349.1 lysophosphatidic acid receptor 1 isoform a
NM_001351419.2 NP_001338348.1 lysophosphatidic acid receptor 1 isoform a
NM_001387475.1 NP_001374404.1 lysophosphatidic acid receptor 1 isoform a
NM_001387479.1 NP_001374408.1 lysophosphatidic acid receptor 1 isoform a
NM_001387489.1 NP_001374418.1 lysophosphatidic acid receptor 1 isoform a
NM_001387472.1 NP_001374401.1 lysophosphatidic acid receptor 1 isoform a
NM_001387511.1 NP_001374440.1 lysophosphatidic acid receptor 1 isoform a
NM_001351406.2 NP_001338335.1 lysophosphatidic acid receptor 1 isoform a
NM_001387496.1 NP_001374425.1 lysophosphatidic acid receptor 1 isoform a
NM_001351402.2 NP_001338331.1 lysophosphatidic acid receptor 1 isoform a
NM_001387486.1 NP_001374415.1 lysophosphatidic acid receptor 1 isoform a
NM_001351412.2 NP_001338341.1 lysophosphatidic acid receptor 1 isoform a
NM_001387505.1 NP_001374434.1 lysophosphatidic acid receptor 1 isoform a
NM_001387504.1 NP_001374433.1 lysophosphatidic acid receptor 1 isoform a
NM_001351400.2 NP_001338329.1 lysophosphatidic acid receptor 1 isoform a
NM_001351408.2 NP_001338337.1 lysophosphatidic acid receptor 1 isoform a
NM_001351418.2 NP_001338347.1 lysophosphatidic acid receptor 1 isoform a
NM_001387488.1 NP_001374417.1 lysophosphatidic acid receptor 1 isoform a
NM_001387493.1 NP_001374422.1 lysophosphatidic acid receptor 1 isoform a
NM_001387473.1 NP_001374402.1 lysophosphatidic acid receptor 1 isoform a
NM_001387498.1 NP_001374427.1 lysophosphatidic acid receptor 1 isoform a
NM_001387514.1 NP_001374443.1 lysophosphatidic acid receptor 1 isoform a
NM_001387490.1 NP_001374419.1 lysophosphatidic acid receptor 1 isoform a
NM_001387521.1 NP_001374450.1 lysophosphatidic acid receptor 1 isoform c
XM_047422903.1 XP_047278859.1 lysophosphatidic acid receptor 1 isoform X1
NM_001387471.1 NP_001374400.1 lysophosphatidic acid receptor 1 isoform a
NM_001351411.2 NP_001338340.1 lysophosphatidic acid receptor 1 isoform a
NM_001387487.1 NP_001374416.1 lysophosphatidic acid receptor 1 isoform a
NM_001387480.1 NP_001374409.1 lysophosphatidic acid receptor 1 isoform a
NM_001387501.1 NP_001374430.1 lysophosphatidic acid receptor 1 isoform a
NM_001387492.1 NP_001374421.1 lysophosphatidic acid receptor 1 isoform a
NM_001351401.2 NP_001338330.1 lysophosphatidic acid receptor 1 isoform a
NM_001387481.1 NP_001374410.1 lysophosphatidic acid receptor 1 isoform a
NM_057159.4 NP_476500.1 lysophosphatidic acid receptor 1 isoform a
NM_001387484.1 NP_001374413.1 lysophosphatidic acid receptor 1 isoform a
NM_001387482.1 NP_001374411.1 lysophosphatidic acid receptor 1 isoform a
NM_001351416.2 NP_001338345.1 lysophosphatidic acid receptor 1 isoform a
NM_001351403.2 NP_001338332.1 lysophosphatidic acid receptor 1 isoform a
NM_001387513.1 NP_001374442.1 lysophosphatidic acid receptor 1 isoform a
NM_001351415.2 NP_001338344.1 lysophosphatidic acid receptor 1 isoform a
NM_001387478.1 NP_001374407.1 lysophosphatidic acid receptor 1 isoform a
NM_001387519.1 NP_001374448.1 lysophosphatidic acid receptor 1 isoform c
NM_001387508.1 NP_001374437.1 lysophosphatidic acid receptor 1 isoform a
NM_001351405.2 NP_001338334.1 lysophosphatidic acid receptor 1 isoform a
NM_001387483.1 NP_001374412.1 lysophosphatidic acid receptor 1 isoform a
NM_001387517.1 NP_001374446.1 lysophosphatidic acid receptor 1 isoform b
NM_001351417.2 NP_001338346.1 lysophosphatidic acid receptor 1 isoform a
NM_001351397.2 NP_001338326.1 lysophosphatidic acid receptor 1 isoform a
NM_001387506.1 NP_001374435.1 lysophosphatidic acid receptor 1 isoform a
NM_001387512.1 NP_001374441.1 lysophosphatidic acid receptor 1 isoform a
NM_001387470.1 NP_001374399.1 lysophosphatidic acid receptor 1 isoform a
NM_001351407.2 NP_001338336.1 lysophosphatidic acid receptor 1 isoform a
NM_001387510.1 NP_001374439.1 lysophosphatidic acid receptor 1 isoform a
NM_001387516.1 NP_001374445.1 lysophosphatidic acid receptor 1 isoform b
NM_001387497.1 NP_001374426.1 lysophosphatidic acid receptor 1 isoform a
NM_001351413.2 NP_001338342.1 lysophosphatidic acid receptor 1 isoform a
NM_001351409.2 NP_001338338.1 lysophosphatidic acid receptor 1 isoform a
NM_001351399.2 NP_001338328.1 lysophosphatidic acid receptor 1 isoform a
NM_001387494.1 NP_001374423.1 lysophosphatidic acid receptor 1 isoform a
NM_001387515.1 NP_001374444.1 lysophosphatidic acid receptor 1 isoform a
NM_001351414.2 NP_001338343.1 lysophosphatidic acid receptor 1 isoform a
NM_001401.5 NP_001392.2 lysophosphatidic acid receptor 1 isoform a
NM_001387476.1 NP_001374405.1 lysophosphatidic acid receptor 1 isoform a
NM_001387477.1 NP_001374406.1 lysophosphatidic acid receptor 1 isoform a
NM_001387485.1 NP_001374414.1 lysophosphatidic acid receptor 1 isoform a
NM_001387491.1 NP_001374420.1 lysophosphatidic acid receptor 1 isoform a
NM_001387495.1 NP_001374424.1 lysophosphatidic acid receptor 1 isoform a
NM_001387518.1 NP_001374447.1 lysophosphatidic acid receptor 1 isoform b
NM_001387474.1 NP_001374403.1 lysophosphatidic acid receptor 1 isoform a
NM_001387503.1 NP_001374432.1 lysophosphatidic acid receptor 1 isoform a
NM_001387502.1 NP_001374431.1 lysophosphatidic acid receptor 1 isoform a
NM_001351398.2 NP_001338327.1 lysophosphatidic acid receptor 1 isoform a
NM_001387520.1 NP_001374449.1 lysophosphatidic acid receptor 1 isoform c
NM_001351410.2 NP_001338339.1 lysophosphatidic acid receptor 1 isoform a
NM_001387509.1 NP_001374438.1 lysophosphatidic acid receptor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysophosphatidic acid binding IDA
IDA: Inferred from direct assay
9070858 GOA
enables lysophosphatidic acid receptor activity IDA
IDA: Inferred from direct assay
19306925 GOA
enables lysophosphatidic acid receptor activity IMP
IMP: Inferred from mutant phenotype
9070858 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19306925 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19306925 GOA
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
19733258 GOA
involved in negative regulation of cilium assembly IDA
IDA: Inferred from direct assay
31204173 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19733258 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: Inferred from expression pattern
12761501 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19306925 GOA
colocalizes with endocytic vesicle IDA
IDA: Inferred from direct assay
19306925 GOA
located in endosome IDA
IDA: Inferred from direct assay
19306925 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19306925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (67 - 311)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 1

  • LPA receptor 1

  • LPA-1

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2

  • lysophosphatidic acid receptor Edg-2

  • ventricular zone gene 1

LPAR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83630 EDG2 Antibody (YA3375) WB, IHC-P, ICC/IF, FC, IP Human

Related Diseases

Diseases Alias
Spinal Stenosis

  • Lumbar Spinal Stenosis

  • Cervical Spinal Stenosis

  • Spinal Stenosis Of Lumbar Region

  • Spinal Stenosis In Cervical Region

  • Spinal Canal Stenosis
Hypotrichosis 8

  • HYPT8

  • Lah3

  • Hypotrichosis, Localized, Autosomal Recessive 3

  • Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis

  • Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis

  • Hypotrichosis Localized Autosomal Recessive 3

  • Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis

  • ARWH1

  • Hypotrichosis, Type 8
Interstitial Lung Disease 2

  • Idiopathic Pulmonary Fibrosis

  • Ipf

  • Fibrocystic Pulmonary Dysplasia

  • Pulmonary Fibrosis, Idiopathic

  • Pulmonary Fibrosis, Idiopathic, Susceptibility To

  • ILD2

  • Idiopathic Pulmonary Fibrosis, Familial

  • Fibrosing Alveolitis, Cryptogenic

  • Uip

  • Cryptogenic Fibrosing Alveolitis

  • Fibrosing Alveolitis

  • Interstitial Pneumonitis, Usual

  • Familial Idiopathic Pulmonary Fibrosis

  • Idiopathic Fibrosing Alveolitis, Chronic Form

  • Usual Interstitial Pneumonia

  • Fibrosing Alveolitis Cryptogenic

  • Hamman-Rich Disease

  • Idiopathic Pulmonary Fibrosis Familial

  • Interstitial Pneumonitis Usual

  • Fibrosis Idiopathic Pulmonary

  • Fibrosis, Pulmonary, Idiopathic

  • Hamman-Rich Syndrome

  • Chronic Idiopathic Pulmonary Fibrosis

  • Acute Interstitial Pneumonia

  • Interstitial Pulmonary Fibrosis

  • Ipf - [Idiopathic Pulmonary Fibrosis]

  • Idiopathic Lung Fibrosis

  • Fibrosing Lung Disease

  • Pulmonary Fibrosis Nos

  • Fibrosing Pneumonitis
Pertussis

  • Whooping Cough

  • Bordetella Infections

  • Bordetella Infection

  • Bordetella Pertussis Infection

  • Wc - Whooping Cough

  • Whooping Cough Due To Unspecified Organism

  • Bordetellosis

  • Tussis Convulsiva

  • Whooping Cough, Unspecified Organism

  • Wc - [Whooping Cough]

  • Whooping Cough Due To B. Parapertussis

  • Infection Due To Bordetella Parapertussis
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Intestinal Pseudo-Obstruction

  • Chronic Intestinal Pseudoobstruction

  • Chronic Intestinal Pseudo-Obstruction

  • Cipo

  • Neuronal Intestinal Dysplasia

  • Hollow Visceral Myopathy

  • Familial Visceral Neuropathy

  • Paralytic Ileus

  • Intestinal Pseudoobstruction

  • Chronic Idiopathic Intestinal Pseudo-Obstruction

  • Ciip

  • Congenital Short Bowel Syndrome

  • Enteric Neuropathy

  • Familial Visceral Myopathy

  • Ipo

  • Pseudo-Obstruction Of Intestine

  • Pseudointestinal Obstruction Syndrome

  • Pseudoobstructive Syndrome

  • Congenital Idiopathic Intestinal Pseudoobstruction

  • Visceral Myopathy, Familial
Pulmonary Fibrosis

  • Fibrosis Of Lung
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Fibrosclerosis Of Breast

  • Fibrosis Of The Breast

  • Breast Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16039 AM095 Antagonist 99.72% Unkown
HY-15706 H2L 5765834 Antagonist 98.66% Unkown
HY-117444 ONO-9780307 Inhibitor 99.94% Unkown
HY-117959 TAK-615 Inhibitor 98.07% Unkown
HY-115450 ONO-0300302 Antagonist 98.02% Unkown
HY-124072 HL001 Antagonist 98.90% Unkown
HY-181931 Autotaxin-IN-8 Inhibitor / Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LPAR1 VGNC VGNC:63261
Bos taurus LPAR1 VGNC VGNC:30955
Mus musculus LPAR1 MGD MGI:108429
Canis familiaris LPAR1 VGNC VGNC:42742
Rattus norvegicus LPAR1 RGD RGD:620563