2. GPCR/G Protein
  3. LPL Receptor
  4. TAK-615

TAK-615 

Cat. No.: HY-117959 Purity: 99.51%
COA Handling Instructions

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM).

For research use only. We do not sell to patients.

TAK-615 Chemical Structure

TAK-615 Chemical Structure

CAS No. : 1664335-55-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 385 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].

IC50 & Target[1]

LPA1 Receptor

1.7-14.5 nM (Kd)

In Vitro

TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity (KdHi) of 1.7±0.5 nM and Kd low affinity (KdLo) of 14.5±12.1 nM[1].
TAK-615 is only able to partially inhibit the LPA response (~ 40% at 10 µM with an IC50 of 23±13 nM in β-arrestin assay; 60% at 10 µM, IC50 of 91±30 nM in calcium mobilisation assay) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

419.44

Appearance

Solid

Formula

C25H22FNO4
CAS No.
SMILES

O=C(O)C1=CC=C(CN(CC2CC2)C(C3=CC=C(OC4=CC=CC=C4F)C=C3)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (298.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3841 mL 11.9207 mL 23.8413 mL
5 mM 0.4768 mL 2.3841 mL 4.7683 mL
10 mM 0.2384 mL 1.1921 mL 2.3841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

TAK-6151664335-55-0TAK615TAK 615LPL ReceptorLysophospholipid ReceptornegativeallostericmodulatorNAMpulmonaryfibrosisLPA1Inhibitorinhibitorinhibit

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