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  2. LPL Receptor
  3. TAK-615

TAK-615 

Cat. No.: HY-117959
Handling Instructions

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM).

For research use only. We do not sell to patients.

TAK-615 Chemical Structure

TAK-615 Chemical Structure

CAS No. : 1664335-55-0

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Description

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].

IC50 & Target[1]

LPA1 Receptor

1.7-14.5 nM (Kd)

LPA1 Receptor

91 nM (IC50)

In Vitro

TAK-615 partially inhibits the LPA response (60% at 10 µM, IC50 of 91±30 nM)[1].

Molecular Weight

419.44

Formula

C₂₅H₂₂FNO₄

CAS No.

1664335-55-0

SMILES

O=C(O)C1=CC=C(CN(CC2CC2)C(C3=CC=C(OC4=CC=CC=C4F)C=C3)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TAK-615TAK615TAK 615LPL ReceptorLysophospholipid ReceptornegativeallostericmodulatorNAMpulmonaryfibrosisLPA1Inhibitorinhibitorinhibit

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TAK-615
Cat. No.:
HY-117959
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