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  2. LPL Receptor
  3. TAK-615

TAK-615 

Cat. No.: HY-117959 Purity: 99.51%
Handling Instructions

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM).

For research use only. We do not sell to patients.

TAK-615 Chemical Structure

TAK-615 Chemical Structure

CAS No. : 1664335-55-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].

IC50 & Target[1]

LPA1 Receptor

1.7-14.5 nM (Kd)

In Vitro

TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity (KdHi) of 1.7±0.5 nM and Kd low affinity (KdLo) of 14.5±12.1 nM[1].
TAK-615 is only able to partially inhibit the LPA response (~ 40% at 10 µM with an IC50 of 23±13 nM in β-arrestin assay; 60% at 10 µM, IC50 of 91±30 nM in calcium mobilisation assay) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

419.44

Formula

C₂₅H₂₂FNO₄

CAS No.

1664335-55-0

SMILES

O=C(O)C1=CC=C(CN(CC2CC2)C(C3=CC=C(OC4=CC=CC=C4F)C=C3)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (298.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3841 mL 11.9207 mL 23.8413 mL
5 mM 0.4768 mL 2.3841 mL 4.7683 mL
10 mM 0.2384 mL 1.1921 mL 2.3841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TAK-615TAK615TAK 615LPL ReceptorLysophospholipid ReceptornegativeallostericmodulatorNAMpulmonaryfibrosisLPA1Inhibitorinhibitorinhibit

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Product Name:
TAK-615
Cat. No.:
HY-117959
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