Nlgn1 - neuroligin 1 Gene

Also Known as NL1; Nlg1; mKIAA1070; 6330415N05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192167

Summary

Enables neurexin family protein binding activity. Involved in several processes, including positive regulation of transport; synapse organization; and synaptic vesicle cycle. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in external side of plasma membrane and synapse. Is integral component of plasma membrane. Part of receptor complex. Is active in glutamatergic synapse. Is expressed in blood vessel and brain. Used to study autism spectrum disorder. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn1 Products (5)

mRNA Protein Name
NM_001163387.2 NP_001156859.1 neuroligin-1 isoform 2
NM_001357095.1 NP_001344024.1 neuroligin-1 isoform 3
NM_001357096.1 NP_001344025.1 neuroligin-1 isoform 4
NM_001357097.1 NP_001344026.1 neuroligin-1 isoform 4
NM_138666.4 NP_619607.2 neuroligin-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neurexin family protein binding IMP
IMP: Inferred from mutant phenotype
10892652 MGI
enables neurexin family protein binding IPI
IPI: Inferred from physical interaction
12796785 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18084303 MGI
Biological Process GO Annotation Evidence References Source
involved in AMPA glutamate receptor clustering IDA
IDA: Inferred from direct assay
12796785 MGI
involved in AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
21940442 MGI
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
12796785 MGI
involved in cytoskeletal matrix organization at active zone IMP
IMP: Inferred from mutant phenotype
19628693 MGI
involved in establishment of protein localization IMP
IMP: Inferred from mutant phenotype
12796785 MGI
involved in excitatory synapse assembly IDA
IDA: Inferred from direct assay
22960622 MGI
involved in excitatory synapse assembly IMP
IMP: Inferred from mutant phenotype
26440732 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
12796785 MGI
NOT involved in inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17582332 MGI
acts upstream of or within modulation of chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
16982420 MGI
involved in negative regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
23143522 MGI
involved in nervous system development IDA
IDA: Inferred from direct assay
10892652 MGI
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
28841651 MGI
involved in neurexin clustering involved in presynaptic membrane assembly IDA
IDA: Inferred from direct assay
12796785 MGI
involved in neuron cell-cell adhesion IDA
IDA: Inferred from direct assay
12796785 MGI
involved in positive regulation of circadian sleep/wake cycle, wakefulness IMP
IMP: Inferred from mutant phenotype
23716671 MGI
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
23143522 MGI
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
17582332 MGI
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
23143522 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
21356198 MGI
involved in positive regulation of synaptic vesicle clustering IDA
IDA: Inferred from direct assay
15620359 MGI
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
19628693 MGI
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
19628693 MGI
involved in postsynaptic density protein 95 clustering IDA
IDA: Inferred from direct assay
12796785 MGI
involved in postsynaptic membrane assembly IDA
IDA: Inferred from direct assay
12796785 MGI
involved in postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
15620359 MGI
involved in postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
15620359 MGI
involved in presynaptic membrane assembly IDA
IDA: Inferred from direct assay
10892652 MGI
involved in protein localization to synapse IDA
IDA: Inferred from direct assay
15620359 MGI
involved in receptor localization to synapse IDA
IDA: Inferred from direct assay
12796785 MGI
involved in regulation of NMDA receptor activity IDA
IDA: Inferred from direct assay
17582332 MGI
involved in regulation of NMDA receptor activity IMP
IMP: Inferred from mutant phenotype
23143522 MGI
involved in regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10892652 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
32324534 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
32324534 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IGI
IGI: Inferred from genetic interaction
16982420 MGI
acts upstream of synapse assembly IDA
IDA: Inferred from direct assay
21356198 MGI
involved in synapse assembly IDA
IDA: Inferred from direct assay
10892652 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
21788371 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
12796785 MGI
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
12796785 MGI
involved in synaptic vesicle clustering IDA
IDA: Inferred from direct assay
10892652 MGI
involved in synaptic vesicle targeting IMP
IMP: Inferred from mutant phenotype
10892652 MGI
involved in terminal button organization IMP
IMP: Inferred from mutant phenotype
19628693 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23791195 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
20573900 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15620359 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15620359 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
10892652 MGI
part of receptor complex IDA
IDA: Inferred from direct assay
12796785 MGI
located in synapse IDA
IDA: Inferred from direct assay
12202822 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroligin-1

Nlgn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Nlgn1 Q99K10 PTPRT Homo sapiens O14522
Anti Tag CoIP
19816407
Cross
Nlgn1 Q99K10 Kalrn Rattus norvegicus P97924-5
Anti Tag CoIP
31801062
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Nlgn1 Proteins

Cat. No. Product Name Accession Purity
HY-P74704 Neuroligin-1/NLGN1 Protein, Mouse (HEK293, His, solution) Q99K10-1 (Q46-S697) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09339 NLGN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19024 Nlgn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25513 Nlgn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlgn1 NCBI NCBI:22871