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Ptpn22 - protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Gene

Also Known as PEP; Ptpn8; 70zpep

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19260

Summary

Enables SH3 domain binding activity and kinase binding activity. Involved in several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within T cell differentiation; T cell receptor signaling pathway; and protein dephosphorylation. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); chronic lymphocytic leukemia; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine Phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn22 Products (3)

mRNA	Protein	Name
NM_001409794.1	NP_001396723.1	tyrosine-protein phosphatase non-receptor type 22 isoform 1
NM_001409795.1	NP_001396724.1	tyrosine-protein phosphatase non-receptor type 22 isoform 2
NM_008979.3	NP_033005.1	tyrosine-protein phosphatase non-receptor type 22 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	8890164	MGI
enables kinase binding	IPI IPI: Inferred from physical interaction	8890164	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15786712	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	27043286	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	14752163	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14752163	MGI
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	23991106	MGI
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	21044313	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	23991106	MGI
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	23991106	MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	23991106	MGI
involved in negative regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	23991106	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	23991106	MGI
involved in phosphoanandamide dephosphorylation	IDA IDA: Inferred from direct assay	16938887	MGI
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23991106	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	27043286	MGI
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of granzyme B production	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	23871208	MGI
acts upstream of or within protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	14752163	MGI
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	1373816	MGI
NOT involved in regulation of antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	23871208	MGI
involved in regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23991106	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8890164	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10940933	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10940933	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 22	PEST domain-enriched tyrosine phosphatase hematopoietic cell protein-tyrosine phosphatase 70Z-PEP protein tyrosine phosphatase, non-receptor type 8

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139693	PTPN22-IN-1	Inhibitor	99.60%	Unkown
HY-156659	NC1	Inhibitor	98.73%	Unkown
HY-155848	LYP-IN-4	Inhibitor	98.60%	Unkown
HY-170564	PTPN22-IN-2	Inhibitor	/	Unkown
HY-183573	PTPRO-IN-1	Inhibitor	/	Unkown
HY-184931	PTPN22-IN-3		/	Unkown
HY-RS11424	PTPN22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17516	Ptpn22 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23973	Ptpn22 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn22	NCBI	NCBI:26191