PTPN22-IN-1 

PTPN22-IN-1 is a potent PTPN22 inhibitor (IC₅₀=1.4 µM; K_i=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses^[1]. From WO2021007491A1 compound L-1.

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects^[1].
? Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 μM h and C_max of 1.1 1 μM (Fig. 9d), which is more than twice of its K_i value^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects^[1].
? Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 μM h and C_max of 1.1 1 μM, which is more than twice of its K_i value^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

455.46

C₂₆H₂₁N₃O₅

2580935-57-3

Solid

White to yellow

O=C1C2=CC(NC([C@H](C)NC(C3=CC=C(C4=CC=CC=C4)C=C3)=O)=O)=CC=C2NC=C1C(O)=O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Elizabeth Jaffee, et al. Targeting ptpn22 in cancer therapy. WO2021007491A1.