1. Others
    Metabolic Enzyme/Protease
  2. Others
    Phosphatase
  3. PTPN22-IN-1

PTPN22-IN-1 

Cat. No.: HY-139693
Handling Instructions

PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1.

For research use only. We do not sell to patients.

PTPN22-IN-1 Chemical Structure

PTPN22-IN-1 Chemical Structure

CAS No. : 2580935-57-3

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Description

PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1.

In Vitro

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1].
Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and Cmax of 1.1 1 µM (Fig. 9d), which is more than twice of its Ki value[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1].
Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and Cmax of 1.1 1 µM (Fig. 9d), which is more than twice of its Ki value[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

455.46

Formula

C₂₆H₂₁N₃O₅

CAS No.
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Product Name:
PTPN22-IN-1
Cat. No.:
HY-139693
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