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Cat. No.: HY-170564

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PTPN22-IN-2

PTPN22-IN-2 (Compound 8b-19) is a PTPN22 inhibitor with an IC₅₀ of 250 nM. PTPN22-IN-2 can be used for research in the field of immunomodulation.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₂ClNO₆
Molecular Weight:503.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PTPN22-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PTPN22-IN-2 (Compound 8b-19) is a PTPN22 inhibitor with an IC₅₀ of 250 nM. PTPN22-IN-2 can be used for research in the field of immunomodulation^[1].

Chemical Information

Molecular Weight 503.93
Formula C₂₈H₂₂ClNO₆
SMILES

OC1=C(C(O)=O)C=C(C(/C=C/C2=CC=CC(Cl)=C2)=C(C3=CC=C(OCC(NC4CC4)=O)C=C3)O5)C5=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jassim BA, et al. Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy. Eur J Med Chem. 2025 Feb 5;283:117129. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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