ELF2 - E74 like ETS transcription factor 2 Gene

Homo sapiens

Also known as EU32; NERF; NERF-2; NERF-1A; NERF-1B; NERF-1a,b

Gene ID: 1998 | Gene type: protein coding

About ELF2

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,057,220-139,177,915 (from NCBI)

This gene has 13 transcripts (splice variants), 200 orthologues and 28 paralogues. Ubiquitous expression in testis (RPKM 17.8), bone marrow (RPKM 13.2) and 25 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

ELF2 Products(11)

mRNA	Protein	Name
NM_001276457.2	NP_001263386.1	ETS-related transcription factor Elf-2 isoform 3
NM_001276458.3	NP_001263387.1	ETS-related transcription factor Elf-2 isoform 4
NM_001276459.3	NP_001263388.1	ETS-related transcription factor Elf-2 isoform 5
NM_001331036.3	NP_001317965.1	ETS-related transcription factor Elf-2 isoform 6
NM_001371324.1	NP_001358253.1	ETS-related transcription factor Elf-2 isoform 1
NM_001371336.1	NP_001358265.1	ETS-related transcription factor Elf-2 isoform 7
NM_001371337.1	NP_001358266.1	ETS-related transcription factor Elf-2 isoform 8
NM_001371338.1	NP_001358267.1	ETS-related transcription factor Elf-2 isoform 9
NM_001371339.1	NP_001358268.1	ETS-related transcription factor Elf-2 isoform 10
NM_006874.5	NP_006865.1	ETS-related transcription factor Elf-2 isoform 2
NM_201999.3	NP_973728.1	ETS-related transcription factor Elf-2 isoform 1

ELF2 Protein Structure

Elf-1_N

Ets

0
100
200
300
400
500
593 a.a.

Protein Preferred Names

Protein Names

ETS-related transcription factor Elf-2

E74-like factor 2 (ets domain transcription factor)

Related Diseases

Diseases

Alias

Cerebellar Ataxia, Neuropathy, And Vestibular Areflexia Syndrome

CANVAS	Cerebellar Ataxia With Neuropathy And Bilateral Vestibular Areflexia Syndrome
Cabv Syndrome	Cerebellar Ataxia With Bilateral Vestibulopathy Syndrome
Ataxia, Cerebellar, Neuropathy, And Vestibular Areflexia Syndrome

Adie Pupil

Adie Syndrome	Holmes-Adie Syndrome
Poorly Reacting Pupils	Adie'S Pupil Or Syndrome
Adie'S Pupil Syndrome	Adie'S Syndrome
Adie'S Pupil	Has
Tonic, Sluggishly Reacting Pupil And Hypoactive Or Absent Tendon Reflexes	Tonic Pupil-Tendon Areflexia Syndrome
ADIEP	Tonic Pupil

Rectum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Rectum	Rectal Squamous Cell Carcinoma
Squamous Carcinoma Of Rectum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04299	ELF2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ELF2	MGD	MGI:1916507
Felis catus	ELF2	VGNC	VGNC:61806
Macaca mulatta	ELF2	VGNC	VGNC:100222
Canis familiaris	ELF2	VGNC	VGNC:40299
Rattus norvegicus	ELF2	RGD	RGD:1310585
Bos taurus	ELF2	VGNC	VGNC:28427
Others	ELF2	NCBI