Sema4a - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Gene

Also Known as SemB; Semab

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20351

Summary

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in several processes, including T-helper 1 cell differentiation; negative regulation of angiogenesis; and positive regulation of synapse assembly. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; primitive ventricle; retina; and ureteric trunk. Human ortholog(s) of this gene implicated in cone-rod dystrophy 10 and retinitis pigmentosa 35. Orthologous to human SEMA4A (semaphorin 4A). [provided by Alliance of Genome Resources, Apr 2022]

Sema4a Products (4)

mRNA Protein Name
NM_001163489.1 NP_001156961.1 semaphorin-4A precursor
NM_001163490.1 NP_001156962.1 semaphorin-4A precursor
NM_001163491.1 NP_001156963.1 semaphorin-4A precursor
NM_013658.3 NP_038686.3 semaphorin-4A precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in T cell differentiation involved in immune response IMP
IMP: Inferred from mutant phenotype
15780988 MGI
involved in T-helper 1 cell differentiation IMP
IMP: Inferred from mutant phenotype
15780988 MGI
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
20043131 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17318185 MGI
involved in positive regulation of excitatory synapse assembly IMP
IMP: Inferred from mutant phenotype
29981480 MGI
involved in positive regulation of inhibitory synapse assembly IMP
IMP: Inferred from mutant phenotype
29981480 MGI
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
20043131 MGI
involved in regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
17318185 MGI
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
20043131 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
17318185 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-4A

  • sema B

  • semaphorin-B

Recombinant Sema4a Proteins

Cat. No. Product Name Accession Purity
HY-P71283 Semaphorin-4A/SEMA4A Protein, Mouse (HEK293, His) Q62178 (T33-H682) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12657 SEMA4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18312 Sema4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24790 Sema4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992388 IO-108 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema4a NCBI NCBI:64218