EPHA3 - EPH receptor A3 Gene

Also Known as EK4; ETK; HEK; ETK1; HEK4; TYRO4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2042

About EPHA3

Cytogenetic location: 3p11.1 Genomic coordinates (GRCh38): 3:89,107,621-89,482,134 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues, 53 paralogues and is associated with 118 phenotypes. Broad expression in prostate (RPKM 12.7), gall bladder (RPKM 11.9) and 18 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

EPHA3 Products (3)

mRNA	Protein	Name
NM_001410778.1	NP_001397707.1	ephrin type-A receptor 3 isoform c precursor
NM_005233.6	NP_005224.2	ephrin type-A receptor 3 isoform a precursor
NM_182644.3	NP_872585.1	ephrin type-A receptor 3 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GPI-linked ephrin receptor activity	IDA IDA: Inferred from direct assay	11870224	GOA
enables ephrin receptor activity	IDA IDA: Inferred from direct assay	11519828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11519828	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	11870224	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	11870224	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	21135139	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11870224	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA3 Protein Structure

Ephrin_lbd

Ephrin_rec_like

fn3

EphA2_TM

Pkinase_Tyr

SAM_2

0
200
400
600
800
983 a.a.

Protein Preferred Names	Protein Names
ephrin type-A receptor 3	EPH-like kinase 4

EPHA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EPHA3	P29320	EPHA7	Homo sapiens	Q15375	Comigration in SDS	22036564
Intra	EPHA3	P29320	EPHA2	Homo sapiens	P29317	BioID	35384245
Intra	EPHA3	P29320	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	35384245
Intra	EPHA3	P29320	EPHA2	Homo sapiens	P29317	Affinity Chrom	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71663	EphA3 Protein, Human (HEK293, His)	P29320-1 (E21-Q541)	≥ 95%, as determined by reducing SDS-PAGE.

EPHA3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81772	EphA3 Antibody (YA1517)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Wet Beriberi
Thiamine Deficiency Disease
Beriberi	Thiamine Deficiency Vitamin B1 Deficiency Aneurin Deficiency Thiamine Vitamin Deficiency Beriberi Nos Beriberi Due To Vitamin B1 Deficiency Beriberi Due To Thiamine Vitamin Deficiency Kakkè
Ciliary Dyskinesia, Primary, 20	Primary Ciliary Dyskinesia 20 CILD20 Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus Ics20 Immotile Cilia Syndrome 20 Dyskinesia, Ciliary, Primary, 20
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Pseudohypoaldosteronism
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18832	AWL-II-38.3	Inhibitor	99.68%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	99.31%	Unkown
HY-146375	UniPR505	Antagonist	99.68%	Unkown
HY-P10579	123B9	Agonist	99.67%	Unkown
HY-10654	EphB4-IN-2	Inhibitor	/	Unkown
HY-RS04427	EPHA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18813	Epha3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25303	Epha3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EPHA3	MGD	MGI:99612
Rattus norvegicus	EPHA3	RGD	RGD:68389
Bos taurus	EPHA3	VGNC	VGNC:54423
Macaca mulatta	EPHA3	VGNC	VGNC:72236
Felis catus	EPHA3	VGNC	VGNC:61903
Canis familiaris	EPHA3	VGNC	VGNC:40406
Others	EPHA3	NCBI