EPHA5 - EPH receptor A5 Gene

Also Known as EK7; CEK7; EHK1; HEK7; EHK-1; TYRO4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2044

About EPHA5

Cytogenetic location: 4q13.1-q13.2 Genomic coordinates (GRCh38): 4:65,319,567-65,670,489 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 53 paralogues. Biased expression in brain (RPKM 4.9), ovary (RPKM 1.0) and 6 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

EPHA5 Products (6)

mRNA Protein Name
NM_001281765.3 NP_001268694.1 ephrin type-A receptor 5 isoform c
NM_001281766.3 NP_001268695.1 ephrin type-A receptor 5 isoform d
NM_001281767.3 NP_001268696.1 ephrin type-A receptor 5 isoform e
NM_001318761.2 NP_001305690.1 ephrin type-A receptor 5 isoform f
NM_004439.8 NP_004430.4 ephrin type-A receptor 5 isoform a
NM_182472.5 NP_872272.2 ephrin type-A receptor 5 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35384245 GOA
Biological Process GO Annotation Evidence References Source
involved in neuron development IEP
IEP: Inferred from expression pattern
10375373 GOA
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
9191074 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
10064801 GOA
located in neuronal cell body IDA
IDA: Inferred from direct assay
10375373 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10375373 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10375373 GOA
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
10375373 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA5 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (60 - 233)

fn3

fn3: Fibronectin type III domain (359 - 448)

fn3

fn3: Fibronectin type III domain (470 - 552)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (575 - 672)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (675 - 932)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (966 - 1027)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1037 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 5

  • EPH homology kinase 1

EPHA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EPHA5 P54756 EPHA2 Homo sapiens P29317
Anti Tag CoIP
35384245
Intra
EPHA5 P54756 EPHA2 Homo sapiens P29317
BioID
35384245
Intra
EPHA5 P54756 EPHA2 Homo sapiens P29317
Affinity Chrom
35384245
Intra
EPHA5 P54756 EPHB4 Homo sapiens P54760
Anti Tag CoIP
35384245
Intra
EPHA5 P54756 EPHB4 Homo sapiens P54760
Affinity Chrom
35384245
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA5 Proteins

Cat. No. Product Name Accession Purity
HY-P77930 EPHA5 Protein, Human (HEK293, His) P54756-1 (A26-P573) ≥ 95%, as determined by Bis-Tris PAGE.

EPHA5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85141 EphA5 Antibody (YA4833) WB, ELISA Human

Related Diseases

Diseases Alias
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Leber Congenital Amaurosis 17

  • LCA17

  • Leber Congenital Amaurosis, Type 17
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04429 EPHA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-RS18661 Epha5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25147 Epha5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992403 MBRC-101 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EPHA5 VGNC VGNC:40408
Bos taurus EPHA5 VGNC VGNC:28535
Felis catus EPHA5 VGNC VGNC:78486
Mus musculus EPHA5 MGD MGI:99654
Macaca mulatta EPHA5 VGNC VGNC:72238
Rattus norvegicus EPHA5 RGD RGD:620831
Others EPHA5 NCBI