Snai1 - snail family zinc finger 1 Gene

Also Known as Sna; Sna1; Snail; Snail1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20613

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of epithelial to mesenchymal transition; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; left/right pattern formation; and negative regulation of cell differentiation involved in embryonic placenta development. Located in cytoplasm; nucleus; and pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy and skin Cancer. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Snai1 Products (1)

mRNA Protein Name
NM_011427.3 NP_035557.1 zinc finger protein SNAI1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12917416 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12917416 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18331720 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9676199 MGI
Biological Process GO Annotation Evidence References Source
involved in Notch signaling pathway IGI
IGI: Inferred from genetic interaction
20890042 MGI
acts upstream of or within cartilage morphogenesis IGI
IGI: Inferred from genetic interaction
17376812 MGI
acts upstream of or within epithelial cell migration IGI
IGI: Inferred from genetic interaction
17376812 MGI
involved in epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
10655586 MGI
involved in epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
11689706 MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation IGI
IGI: Inferred from genetic interaction
18663143 MGI
acts upstream of or within hair follicle morphogenesis IDA
IDA: Inferred from direct assay
15630473 MGI
involved in heterochromatin organization IMP
IMP: Inferred from mutant phenotype
24239292 MGI
acts upstream of or within left/right pattern formation IMP
IMP: Inferred from mutant phenotype
16801545 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
16801545 MGI
involved in mesoderm formation IMP
IMP: Inferred from mutant phenotype
11689706 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10655586 MGI
acts upstream of or within negative regulation of cell differentiation involved in embryonic placenta development IDA
IDA: Inferred from direct assay
9676199 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9676199 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12917416 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10655586 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12832491 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20890042 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20890042 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9676199 MGI
acts upstream of or within roof of mouth development IGI
IGI: Inferred from genetic interaction
17376812 MGI
acts upstream of or within trophoblast giant cell differentiation IDA
IDA: Inferred from direct assay
9676199 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12832491 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12832491 MGI
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
24239292 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein SNAI1

  • snail homolog 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10456 TAK-715 99.76% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13470 SNAI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P5291 CPF-7 / Unkown
HY-RS19742 Snai1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26238 Snai1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snai1 NCBI NCBI:6615