Srebf2 - sterol regulatory element binding factor 2 Gene

Also Known as nuc; lop13; SREBP2; bHLHd2; SREBP-2; SREBP2gc

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20788

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within Cholesterol homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; limb; nervous system; and retina. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Srebf2 Products (2)

mRNA Protein Name
NM_001411792.1 NP_001398721.1 sterol regulatory element-binding protein 2 isoform 2
NM_033218.2 NP_150087.1 sterol regulatory element-binding protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11829742 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11739104 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
33942715 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
11739104 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol homeostasis IGI
IGI: Inferred from genetic interaction
20466882 MGI
involved in positive regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
33942715 MGI
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
23823476 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
33942715 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16890542 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12242332 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16100574 MGI
located in membrane IDA
IDA: Inferred from direct assay
11090130 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10397761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sterol regulatory element-binding protein 2

  • sterol regulatory element-binding transcription factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13758 SREBF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21946 Srebf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179526 Sino-C / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srebf2 NCBI NCBI:6721