2. Gene
  3. Stat5b - signal transducer and activator of transcription 5B Gene

Stat5b - signal transducer and activator of transcription 5B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 20851 | Gene type: protein coding

About Stat5b

Chromosome 11: 100,671,557-100,741,550 reverse strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 286 orthologues, 6 paralogues and is associated with 26 phenotypes. Ubiquitous expression in thymus adult (RPKM 41.1), ovary adult (RPKM 18.1) and 27 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b Products(3)

mRNA Protein Name
NM_001113563.2 NP_001107035.1 signal transducer and activator of transcription 5B
NM_011489.3 NP_035619.3 signal transducer and activator of transcription 5B
NM_001362682.1 NP_001349611.1 signal transducer and activator of transcription 5B

Stat5b Protein Structure

STAT_int

STAT_int: pfam02865 (1 - 123)

STAT5_CCD

STAT5_CCD: cd16855 (138 - 329)

STAT5_DBD

STAT5_DBD: cd16849 (331 - 488)

SH2_STAT5b

SH2_STAT5b: cd10420 (572 - 716)

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  • 786 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 5B

mammary gland factor STAT5B

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112647 Stafib-1 Inhibitor ≥98.0% Unkown
HY-136546 Stafia-1 Inhibitor 99.37% Unkown
HY-148813 AK-2292 99.73% Unkown
HY-19527 IST5-002 99.36% Unkown
HY-112648 Stafib-2 Inhibitor 98.42% Unkown
HY-112649 Pomstafib-2 / Unkown
HY-RS13893 STAT5B Human Pre-designed siRNA Set A / Unkown
HY-RS13894 Stat5b Mouse Pre-designed siRNA Set A / Unkown
HY-RS13895 Stat5b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat5b NCBI NCBI:6777