Stk10 - serine/threonine kinase 10 Gene

Also Known as Lok; Gek1; mKIAA4026

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20868

Summary

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]

Stk10 Products (3)

mRNA Protein Name
NM_001359177.1 NP_001346106.1 serine/threonine-protein kinase 10 isoform 2
NM_001359178.1 NP_001346107.1 serine/threonine-protein kinase 10 isoform 3
NM_009288.2 NP_033314.2 serine/threonine-protein kinase 10 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in lymphocyte aggregation IMP
IMP: Inferred from mutant phenotype
10692593 MGI
involved in regulation of lymphocyte migration IMP
IMP: Inferred from mutant phenotype
19255442 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase 10

  • germ cell kinase 1

  • lymphocyte-oriented kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132868 SLK/STK10-IN-1 Inhibitor 99.78% Unkown
HY-108333 SB-633825 Inhibitor 98.05% Unkown
HY-150782 UNC-CA359 Inhibitor / Unkown
HY-178974 STK10-IN-1 Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-RS13920 STK10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17559 Stk10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24017 Stk10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stk10 NCBI NCBI:6793