STK10 - serine/threonine kinase 10 Gene

Also Known as LOK; PRO2729

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6793

About STK10

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,042,079-172,188,224 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues and 35 paralogues. Broad expression in spleen (RPKM 23.3), bone marrow (RPKM 21.8) and 23 other tissues.

Summary

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

STK10 Products (1)

mRNA Protein Name
NM_005990.4 NP_005981.3 serine/threonine-protein kinase 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18239682 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12639966 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
18239682 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18239682 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
12639966 GOA
involved in regulation of lymphocyte migration IMP
IMP: Inferred from mutant phenotype
19255442 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19255442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK10 Protein Structure

Pkinase

Pkinase: Protein kinase domain (36 - 294)

PKK

PKK: Polo kinase kinase (586 - 725)

PKK

PKK: Polo kinase kinase (754 - 895)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 968 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 10

  • lymphocyte-oriented kinase

STK10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK10 O94804 STK10 Homo sapiens O94804
X-Ray Diffraction
18239682
Intra
STK10 O94804 NONO Homo sapiens Q15233
Crosslink
30021884
Intra
STK10 O94804 STK10 Homo sapiens O94804
Crosslink
18239682
Intra
STK10 O94804 STK10 Homo sapiens O94804
Solution Sedimentation
18239682
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK10 Proteins

Cat. No. Product Name Accession Purity
HY-P73282 LOK Protein, Human (Active, His) O94804 (R18-E317) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Testicular Germ Cell Tumor

  • Male Germ Cell Tumor

  • Testicular Teratoma

  • TGCT

  • Mgct

  • Male Germ Cell Tumor, Somatic

  • Spermatocytic Seminoma, Somatic

  • Embryonal Cell Carcinoma

  • Seminoma

  • Spermatocytic Seminoma

  • Germ Cell Tumors, Somatic

  • Testicular Tumor, Somatic

  • Non-Seminomatous Germ Cell Tumor Of Testis

  • Non-Dysgerminomatous Germ Cell Tumor Of Testis

  • Testicular Non Seminomatous Germ Cell Tumor

  • Testicular Non-Dysgerminomatous Germ Cell Tumor

  • Teratoma Of The Testis

  • Endodermal Sinus Tumor

  • Nonseminomatous Germ Cell Tumors

  • Teratoma Testicular

  • Germ Cell Tumor, Somatic

  • Embryonal Carcinoma Cell

  • Yolk Sac Tumor

  • Malignant Testicular Non-Seminomatous Germ Cell Tumor

  • Testicular Non-Seminomatous Germ Cell Tumor

  • Teratoma Of Testis

  • Nonseminomatous Germ Cell Tumor
Germ Cell Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132868 SLK/STK10-IN-1 Inhibitor 99.78% Unkown
HY-108333 SB-633825 Inhibitor 98.05% Unkown
HY-150782 UNC-CA359 Inhibitor / Unkown
HY-178974 STK10-IN-1 Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-RS13920 STK10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17559 Stk10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24017 Stk10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STK10 MGD MGI:1099439
Rattus norvegicus STK10 RGD RGD:3779
Bos taurus STK10 VGNC VGNC:35384
Macaca mulatta STK10 VGNC VGNC:81582
Canis familiaris STK10 VGNC VGNC:46904
Felis catus STK10 VGNC VGNC:97646
Others STK10 NCBI