Gpr139 - G protein-coupled receptor 139 Gene

Mus musculus

Also known as PGR3; GPRg1; Gm495

Gene ID: 209776 | Gene type: protein coding

About Gpr139

Chromosome 7: 118,739,970-118,783,826 reverse strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 335 orthologues, 1 paralogue and is associated with 8 phenotypes. Biased expression in whole brain E14.5 (RPKM 4.1), CNS E18 (RPKM 3.7) and 5 other tissues.

Summary

Enables identical protein binding activity and neuropeptide receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; ileum; male reproductive gland or organ; and nervous system. Orthologous to human GPR139 (G protein-coupled receptor 139). [provided by Alliance of Genome Resources, Apr 2022]

Gpr139 Products(1)

mRNA	Protein	Name
NM_001024138.2	NP_001019309.1	probable G-protein coupled receptor 139

Gpr139 Protein Structure

7tmA_GPR139

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

probable G-protein coupled receptor 139

G protein-coupled receptor PGR3	g(q)-coupled orphan receptor GPRg1
orphan G protein-coupled receptor TRHRL2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132228	Zelatriazin	Agonist	99.89%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19838	JNJ-63533054	Agonist	99.90%	Unkown
HY-128057	NCRW0005-F05	Antagonist	≥99.0%	Unkown
HY-119168	LP-471756	Antagonist	99.69%	Unkown
HY-101777	TC-O 9311	Agonist	99.70%	Unkown
HY-149651	GPR139 agonist-2	Agonist	99.80%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpr139	NCBI	NCBI:124274

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