Tap1 - transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Gene

Also Known as Y3; TAP; APT1; Ham1; MTP1; PSF1; ABC17; Abcb2; Ham-1; RING4; Tap-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21354

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Tap1 Products (2)

mRNA Protein Name
NM_001161730.1 NP_001155202.1 antigen peptide transporter 1 isoform 2
NM_013683.2 NP_038711.2 antigen peptide transporter 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ABC-type peptide antigen transporter activity EXP
EXP: Inferred from Experiment
8342042 MGI
enables MHC class I protein binding IPI
IPI: Inferred from physical interaction
14735325 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
1473153 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

antigen peptide transporter 1

  • ABC transporter, MHC, 1

  • ATP dependent transport protein family member

  • ATP-binding cassette sub-family B member 2

  • ATP-binding cassette transporter, major histocompatibility complex, 1

  • ATP-binding cassette, sub-family B (MDR/TAP), member 2

  • histocompati

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14201 TAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17593 Tap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-D3417 BO-TAP-1 / Unkown
HY-P5865 Tap1a Inhibitor / Unkown
HY-RS12607 SEC14L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24053 Tap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tap1 NCBI NCBI:6890