Tbp - TATA box binding protein Gene

Also Known as Gtf2d; SCA17; TFIID; GTF2D1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21374

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within transcription by RNA polymerase II and transcription by RNA polymerase III. Located in cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Used to study spinocerebellar ataxia type 17. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tbp Products (1)

mRNA	Protein	Name
NM_013684.3	NP_038712.3	TATA-box-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601870	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21245044	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19235719	MGI
contributes to protein binding	IPI IPI: Inferred from physical interaction	10215616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9050847	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12411709	MGI
acts upstream of or within transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	12411709	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase transcription factor SL1 complex	IPI IPI: Inferred from physical interaction	28893950	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12665565	MGI
located in female germ cell nucleus	IDA IDA: Inferred from direct assay	17641088	MGI
located in female pronucleus	IDA IDA: Inferred from direct assay	17641088	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	12665565	MGI
located in male pronucleus	IDA IDA: Inferred from direct assay	17641088	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11861477	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	22323595	MGI
located in pronucleus	IDA IDA: Inferred from direct assay	16822332	MGI
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	28893950	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TATA-box-binding protein	TATA sequence-binding protein TATA-binding factor TATA-binding protein TATA-box factor TFIID core protein transcription initiation factor TFIID TBP subunit

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16579A	Etifoxine	Activator	99.27%	Phase 3
HY-105056	Bretazenil	Agonist	99.13%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16579	Etifoxine hydrochloride	Activator	99.83%	Yes
HY-105567A	Carbiphene hydrochloride	Antagonist	/	Unkown
HY-114811	Leptophos oxon	Inhibitor	/	Unkown
HY-172940	TBP-134	Inducer	/	Unkown
HY-RS14266	TBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-105567	Carbiphene	Antagonist	/	Unkown
HY-RS18225	Tbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24702	Tbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbp	NCBI	NCBI:6908