FABP2 - fatty acid binding protein 2 Gene

Also Known as FABPI; I-FABP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2169

About FABP2

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:119,317,250-119,322,138 (from NCBI)

This gene has 1 transcript (splice variant), 263 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 287.0), duodenum (RPKM 142.3) and 1 other tissue.

Summary

The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]

FABP2 Products (1)

mRNA	Protein	Name
NM_000134.4	NP_000125.2	fatty acid-binding protein, intestinal

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables long-chain fatty acid binding	IDA IDA: Inferred from direct assay	7883976	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intestinal lipid absorption	IMP IMP: Inferred from mutant phenotype	7883976	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FABP2 Protein Structure

Lipocalin

0
100
132 a.a.

Protein Preferred Names	Protein Names
fatty acid-binding protein, intestinal	fatty acid binding protein 2, intestinal

FABP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FABP2	P12104	AGR2	Homo sapiens	O95994	Validated Y2H	25416956
Intra	FABP2	P12104	AGR2	Homo sapiens	O95994	Y2H Bait-Prey Pool	25910212
Intra	FABP2	P12104	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	25416956
Intra	FABP2	P12104	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FABP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70284	FABP2/I-FABP Protein, Human (His)	AAH69466.1 (M1-D132)	≥ 95%, as determined by reducing SDS-PAGE.

FABP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83043	I-FABP Antibody (YA2788)	WB	Human, Mouse, Rat
HY-P84073	I-FABP Antibody (YA3770)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84073A	I-FABP Antibody (YA3770)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Acute Vascular Insufficiency Of Intestine	Acute Gastrointestinal Tract Vascular Insuffic. Acute Git Vascular Insuffic. Acute Intestinal Ischemia Acute Intestinal Vascular Insufficiency
Intestinal Atresia
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Ileitis	Crohn'S Ileitis
Chronic Intestinal Vascular Insufficiency	Chronic Mesenteric Ischemia Cmi - Chronic Mesenteric Ischaemia
Enterocolitis
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Blind Loop Syndrome	Bacterial Overgrowth Syndrome
Median Arcuate Ligament Syndrome	Celiac Artery Compression Syndrome Dunbar Syndrome Mals Harjola-Marable Syndrome Marable'S Syndrome Celiac Axis Syndrome
Piebald Trait	Piebaldism PBT Partial Albinism Albinoidism, Oculocutaneous, Autosomal Dominant
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Volvulus Of Midgut	Volvulus Intestinal Volvulus Intestinal Malrotation, Familial Familial Intestinal Malrotation Twist Of Intestine, Bowel, Or Colon
Wheat Allergy	Wheat Allergic Reaction Wheat Hypersensitivity Allergy To Wheat Allergy Wheat
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Diabetes Mellitus	Diabetes
Intestinal Perforation	Perforation Of Intestine
Ischemic Colitis	Colitis, Ischemic Irreversible Ischaemic Colitis
Prediabetes Syndrome	Prediabetes Impaired Glucose Tolerance Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101082	N6,2′-O-Dimethyladenosine	Inhibitor	99.87%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04658	FABP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18276	Fabp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24754	Fabp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FABP2	VGNC	VGNC:40560
Felis catus	FABP2	VGNC	VGNC:62035
Macaca mulatta	FABP2	VGNC	VGNC:106574
Mus musculus	FABP2	MGD	MGI:95478
Rattus norvegicus	FABP2	RGD	RGD:2591
Others	FABP2	NCBI