Tff2 - trefoil factor 2 (spasmolytic protein 1) Gene

Also Known as SP; mSP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21785

Summary

Enables CXCR4 Chemokine Receptor binding activity. Acts upstream of or within several processes, including negative regulation of gastric acid secretion; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; liver; skeleton; and thymus. Orthologous to human TFF2 (trefoil factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tff2 Products (1)

mRNA Protein Name
NM_009363.3 NP_033389.2 trefoil factor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CXCR4 chemokine receptor binding IDA
IDA: Inferred from direct assay
19064997 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium-mediated signaling IDA
IDA: Inferred from direct assay
19064997 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11805131 MGI
acts upstream of or within chemokine-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
19064997 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11805131 MGI
acts upstream of gastric acid secretion IMP
IMP: Inferred from mutant phenotype
11805131 MGI
acts upstream of macrophage activation IMP
IMP: Inferred from mutant phenotype
17101660 MGI
acts upstream of or within negative regulation of gastric acid secretion IMP
IMP: Inferred from mutant phenotype
11805131 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
17101660 MGI
acts upstream of or within negative regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
17101660 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
19064997 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
19064997 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11805131 MGI
acts upstream of or within regulation of cell migration IGI
IGI: Inferred from genetic interaction
19064997 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19064997 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

trefoil factor 2

  • spasmolytic polypeptide

Recombinant Tff2 Proteins

Cat. No. Product Name Accession Purity
HY-P71355 TFF2 Protein, Mouse (HEK293, His) Q03404 (E24-Y129) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14423 TFF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17899 Tff2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24368 Tff2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tff2 NCBI NCBI:7032