TFF2 - trefoil factor 2 Gene

Also Known as SP; SML1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7032

About TFF2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,346,357-42,350,994 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 2591.2).

Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two Other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF2 Products (1)

mRNA Protein Name
NM_005423.5 NP_005414.1 trefoil factor 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFF2 Protein Structure

Trefoil

Trefoil: Trefoil (P-type) domain (30 - 72)

Trefoil

Trefoil: Trefoil (P-type) domain (80 - 121)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

trefoil factor 2

  • spasmolysin

TFF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TFF2 Q03403 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
TFF2 Q03403 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
TFF2 Q03403 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
TFF2 Q03403 FCRL4 Homo sapiens Q96PJ5
Protein Array
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TFF2 Proteins

Cat. No. Product Name Accession Purity
HY-P71354 TFF2 Protein, Human (HEK293, His) Q03403 (E24-Y129) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71929A TFF2 Protein, Human (His) Q03403 (E24-Y129) ≥ 95%, as determined by reducing SDS-PAGE.

TFF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83205 Trefoil Factor 2 Antibody (YA2950) WB Human

Related Diseases

Diseases Alias
Gastritis

  • Acute Gastric Mucosal Erosion

  • Erosive Gastritis

  • Erosive Gastropathy

  • Gastritis Erosive

  • Idiopathic Erosive/Hemorrhagic Gastritis

  • Inflammation Of Gastric Mucosa

  • Gastroduodenitis

  • Gastritis Nos

  • Noninfectious Gastroenteritis

  • Nonbacterial Gastroenteritis Of Infant

  • Acute Gastric Infection

  • Acute Simple Gastritis

  • Chronic Antral Gastritis

  • Chronic Fundal Gastritis

  • Chronic Simple Gastritis

  • Acute Gastroduodenitis

  • Acute Antral Gastritis

  • Acute Erosive Gastritis

  • Bile Reflux Gastritis

  • Gastritis Due To Biliary Reflux
Atrophic Gastritis

  • Gastritis, Atrophic

  • Gastric Atrophy

  • Gastritis Atrophic
Alcoholic Gastritis

  • Alcoholic Gastritis, With Hemorrhage

  • Alcoholic Gastritis, Without Mention Of Hemorrhage

  • Alcohol Gastritis

  • Etoh Gastritis
Febrile Seizures, Familial, 1

  • FEB1

  • Convulsions, Familial Febrile, 1

  • Familial Febrile Seizures 1

  • Familial Febrile Convulsions 1
Papillary Adenofibroma
Autoimmune Gastritis
Gastric Ulcer

  • Stomach Ulcer

  • Acute Gastric Ulcer With Haemorrhage And Perforation

  • Acute Gastric Ulcer With Hemorrhage And Obstruction

  • Acute Gastric Ulcer With Hemorrhage And Perforation

  • Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

  • Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

  • Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

  • Acute Gastric Ulcer With Hemorrhage, With Obstruction

  • Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

  • Acute Gastric Ulcer With Perforation

  • Acute Gastric Ulcer With Perforation And Obstruction

  • Acute Gastric Ulcer With Perforation, With Obstruction

  • Acute Gastric Ulcer Without Hemorrhage And Without Perforation

  • Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

  • Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

  • Bleeding Acute Gastric Ulcer

  • Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

  • Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

  • Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

  • Gastric Ulcers

  • Cushings Ulcer

  • Cushing'S Ulcer Of Stomach

  • Peptic Ulcer Of Stomach

  • Mucosal Defect Of The Stomach
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Colitis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Gastritis, Familial Giant Hypertrophic

  • Menetrier Disease

  • Gastric Mucosal Hypertrophy

  • Giant Hypertrophic Gastritis

  • Hypertrophic Gastropathy

  • Gastritis, Hypertrophic

  • Familial Giant Hypertrophic Gastritis

  • Giant Rugal Hypertrophy Of Stomach

  • Hypertrophic Gastritis

  • Gastroenteropathy, Protein Losing

  • Giant Hypertrophic Gastropathy

  • Giant Hypertrophy Of The Gastric Mucosa

  • Hypoproteinemic Hypertrophic Gastropathy

  • Menetrier'S Disease

  • Giant Hypertrophic Hypersecretory Gastritis
Gastrointestinal Adenoma

  • Gi Adenoma

  • Digestive System Adenoma
Microinvasive Gastric Cancer

  • Early Gastric Cancer

  • Surface Gastric Cancer
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diffuse Gastric Cancer

  • Hereditary Diffuse Gastric Adenocarcinoma

  • Hereditary Diffuse Gastric Cancer

  • Signet Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma

  • Signet Ring Cell Gastric Carcinoma

  • Signet Ring Gastric Carcinoma

  • Fdgc

  • Familial Diffuse Cancer Of Stomach

  • Familial Diffuse Gastric Cancer

  • Gastric Cancer, Familial Diffuse

  • Gastric Cancer, Hereditary Diffuse

  • Hdgc

  • Hereditary Diffuse Cancer Of Stomach

  • Diffuse Gastric Cancer Syndrome

  • Cancer, Gastric, Diffuse

  • Carcinoma, Signet Ring Cell

  • Gastric Signet Ring Carcinoma
Retinitis Pigmentosa 39

  • RP39

  • Retinitis Pigmentosa, Type 39
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14423 TFF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17899 Tff2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24368 Tff2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TFF2 VGNC VGNC:35791
Canis familiaris TFF2 VGNC VGNC:47297
Mus musculus TFF2 MGD MGI:1306805
Felis catus TFF2 VGNC VGNC:66120
Macaca mulatta TFF2 VGNC VGNC:78327
Rattus norvegicus TFF2 RGD RGD:620709
Others TFF2 NCBI