Tgm2 - transglutaminase 2, C polypeptide Gene

Also Known as TG2; tTG; G[a]h; tTGas; TGase2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21817

Summary

Enables protein-glutamine gamma-glutamyltransferase activity. Involved in cellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (Transglutaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgm2 Products (1)

mRNA Protein Name
NM_009373.3 NP_033399.1 protein-glutamine gamma-glutamyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein-glutamine gamma-glutamyltransferase activity IMP
IMP: Inferred from mutant phenotype
11113189 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15970210 MGI
involved in negative regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24349085 MGI
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
11274171 MGI
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24349085 MGI
involved in regulation of apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
12810961 MGI
acts upstream of or within salivary gland cavitation IMP
IMP: Inferred from mutant phenotype
15970210 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-glutamine gamma-glutamyltransferase 2

  • C polypeptide

  • TG(C)

  • TGC

  • TGase C

  • TGase II

  • TGase-2

  • isopeptidase TGM2

  • protein-glutamine deamidase TGM2

  • protein-glutamine dopaminyltransferase TGM2

  • protein-glutamine histaminyltransferase TGM2

  • protein-glutamine noradrenalinyltransferase TGM2

  • protei

Recombinant Tgm2 Proteins

Cat. No. Product Name Accession Purity
HY-P78361 TGM2/Transglutaminase 2 Protein, Mouse (His) P21981 (A2-A686) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128595 MT-4 Inhibitor 99.84% Unkown
HY-177133 Suvigletistat Inhibitor 99.82% Unkown
HY-181732 PROTAC TG2 Degrader-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgm2 NCBI NCBI:7052