Thra - thyroid hormone receptor alpha Gene

Also Known as Rvr; Erba; Nr1a1; Thra1; Thra2; T3R[a]; T3Ralpha; c-erbA-1; c-erbAalpha; c-erbA-alpha; 6430529J03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21833

Summary

The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid Hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Thra Products (2)

mRNA Protein Name
NM_001313983.1 NP_001300912.1 thyroid hormone receptor alpha isoform 1
NM_178060.4 NP_835161.1 thyroid hormone receptor alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables DNA binding IDA
IDA: Inferred from direct assay
16322094 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
17952069 MGI
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
15322135 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11641275 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15340084 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19001373 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9927422 MGI
acts upstream of or within cartilage condensation IMP
IMP: Inferred from mutant phenotype
9250685 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18203951 MGI
acts upstream of or within female courtship behavior IMP
IMP: Inferred from mutant phenotype
10769387 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
17129617 MGI
involved in mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8910441 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11641275 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
9250685 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
21652727 MGI
acts upstream of or within positive regulation of female receptivity IMP
IMP: Inferred from mutant phenotype
10769387 MGI
involved in positive regulation of thyroid hormone receptor signaling pathway IDA
IDA: Inferred from direct assay
8910441 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15340084 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8910441 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19001373 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
9430637 MGI
acts upstream of or within regulation of lipid catabolic process IMP
IMP: Inferred from mutant phenotype
12869545 MGI
acts upstream of or within regulation of myeloid cell apoptotic process IMP
IMP: Inferred from mutant phenotype
18203951 MGI
acts upstream of or within regulation of thyroid hormone receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12869545 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
12869545 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
11773436 MGI
acts upstream of or within type I pneumocyte differentiation IGI
IGI: Inferred from genetic interaction
22001906 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
8910441 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17952069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyroid hormone receptor alpha

  • TR alpha 1

  • TR alpha 2

  • nuclear receptor subfamily 1 group A member 1

Thra Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Thra P63058 Cacnb4 Rattus norvegicus D4A055
Anti Tag CoIP
22892567
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14499 THRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17595 Thra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24055 Thra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thra NCBI NCBI:7067