Cacnb4 - calcium voltage-gated channel auxiliary subunit beta 4 Gene

Also Known as CAB4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58942

Summary

Enables protein kinase binding activity and voltage-gated Calcium Channel activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of protein localization to nucleolus; and positive regulation of voltage-gated Calcium Channel activity. Located in cytoplasm; nuclear speck; and nucleolus. Is active in presynapse. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb4 Products (2)

mRNA Protein Name
NM_001105733.2 NP_001099203.1 voltage-dependent L-type calcium channel subunit beta-4 isoform 2
NM_001399143.1 NP_001386072.1 voltage-dependent L-type calcium channel subunit beta-4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11988102 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
18205403 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
12821675 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
12821675 RGD
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
28587927 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
28587927 RGD
involved in positive regulation of protein localization to nucleolus IDA
IDA: Inferred from direct assay
28587927 RGD
involved in positive regulation of voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
12821675 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
28587927 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
10931840 RGD
is active in presynapse IMP
IMP: Inferred from mutant phenotype
10931840 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit beta-4

  • calcium channel beta 4 subunit

  • calcium channel voltage-dependent subunit beta 4

  • calcium channel, voltage-dependent, beta 4 subunit

Cacnb4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Cacnb4 D4A055 Thra Mus musculus P63058
Y2H
22892567
Cross
Cacnb4 D4A055 Ppp2r5d Mus musculus Q91V89
Y2H
22892567
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149662 TMDJ-035 Inhibitor 99.92% Unkown
HY-RS01808 CACNB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacnb4 NCBI NCBI:785