Thy1 - thymus cell antigen 1, theta Gene

Also Known as T25; CD90; Thy-1; Thy1.1; Thy1.2; Thy-1.2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21838

Summary

This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and Other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]

Thy1 Products (1)

mRNA	Protein	Name
NM_009382.3	NP_033408.1	thy-1 membrane glycoprotein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IMP IMP: Inferred from mutant phenotype	18346467	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	9576104	MGI
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	22479590	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18346467	MGI
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9285719	MGI
involved in negative regulation of neuron projection regeneration	IMP IMP: Inferred from mutant phenotype	22479590	MGI
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18346467	MGI
involved in regulation of Rho-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18346467	MGI
involved in retinal cone cell development	IMP IMP: Inferred from mutant phenotype	10567740	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	15677725	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7983148	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11086982	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11086982	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	17341485	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	11086982	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	11086982	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	11086982	MGI
is active in presynapse	IMP IMP: Inferred from mutant phenotype	11086982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
thy-1 membrane glycoprotein	thy-1 antigen

Recombinant Thy1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74515	Thy1/CD90 Protein, Mouse (HEK293, His)	P01831 (Q20-C131)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12953	R-268712	Inhibitor	99.92%	Unkown
HY-117738	Benarthin	Inhibitor	95.79%	Unkown
HY-RS14511	THY1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106611	Brinazarone	Inhibitor	/	Unkown
HY-RS17457	Thy1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23914	Thy1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990157	Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1)	Inhibitor	95.00%	Unkown
HY-P990156	Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Thy1	NCBI	NCBI:7070