THY1 - Thy-1 cell surface antigen Gene

Also Known as CD90; CDw90

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7070

About THY1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,415,476-119,424,985 (from NCBI)

This gene has 10 transcripts (splice variants) and 130 orthologues. Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues.

Summary

This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

THY1 Products (4)

mRNA	Protein	Name
NM_001311160.2	NP_001298089.1	thy-1 membrane glycoprotein isoform 1 preproprotein
NM_001311162.2	NP_001298091.1	thy-1 membrane glycoprotein isoform 1 preproprotein
NM_001372050.1	NP_001358979.1	thy-1 membrane glycoprotein isoform 2 precursor
NM_006288.5	NP_006279.2	thy-1 membrane glycoprotein isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IMP IMP: Inferred from mutant phenotype	18346467	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	15004192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7513706	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	15004192	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18346467	GOA
involved in positive regulation of cellular extravasation	IDA IDA: Inferred from direct assay	15004192	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18346467	GOA
involved in regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9749990	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14757759	GOA
located in cell surface	IDA IDA: Inferred from direct assay	9749990	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THY1 Protein Structure

0
100
161 a.a.

Protein Preferred Names	Protein Names
thy-1 membrane glycoprotein	Thy-1 T-cell antigen

THY1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THY1	P04216	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	THY1	P04216	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	THY1	P04216	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THY1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74516	Thy1/CD90 Protein, Human (HEK293, His)	P04216 (Q20-C130)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74517	Thy1/CD90 Protein, Human (HEK293, Fc)	P04216 (Q20-C130)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74518	Thy1/CD90 Protein, Human (HEK293)	P04216/NP_006279.2(Q20-C130)	≥ 95%, as determined by reducing SDS-PAGE.

THY1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80069	CD90/Thy-1 Antibody (YA523)	WB, IHC-P	Human, Rat
HY-P81132	CD90/Thy-1 Antibody	WB, IHC-P, ICC/IF	Human
HY-P83940	CD90/Thy-1 Antibody (YA3637)	WB, IHC-P, ICC/IF, ELISA	Human, Rat
HY-P83940A	CD90/Thy-1 Antibody (YA3637)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Rat
HY-P85011	CD90/Thy-1 Antibody (YA4703)	ELISA, FC	Human
HY-P86097	CD90/Thy-1 Antibody (YA5789)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Mesangial Proliferative Glomerulonephritis	Glomerulonephritis - Mesangial Proliferative Mesangial Proliferative Gn Mesangioproliferative Glomerulonephritis Glomerulonephritis Mesangial Proliferative
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Adhesions Of Uterus	Intrauterine Adhesions Intrauterine Synechiae Band Of Uterus Asherman Syndrome Internal Adhesion Of Uterus Internal Band Of Uterus
Anal Fistula	Anorectal Fistula Rectal Fistula Allingham Ulcer Perianal Fistula Fistula In Ano Anorectum Fistula
Dental Pulp Disease	Dental Pulp Diseases Dental Pulp Disorder Disorder Of Pulp Of Tooth Pulp Disorder
Dental Pulp Necrosis	Pulp Necrosis Necrotic Pulp Necrosis Of The Pulp Dead Pulp Devitalised Pulp Putrescent Pulpitis Devitalized Tooth Dental Pulp Gangrene Pulp Gangrene Nonvital Tooth Pulpless Tooth Putrescent Pulp
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Limb Ischemia
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Tibial Nerve Palsy
Cartilage Disease	Cartilage Diseases Cartilage Cartilage Disorder Chondropathy Cartilage Disorders
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Inflammatory Bowel Disease 14	IBD14 Inflammatory Bowel Disease 14, Susceptibility To Bowel Disease, Inflammatory, Type 14
Spinocerebellar Ataxia 45	SCA45 Spinocerebellar Ataxia Type 45
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Epilepsy, Familial Temporal Lobe, 2	Familial Temporal Lobe Epilepsy 2 Temporal Epilepsy, Familial ETL2 Ftle Epilepsy, Familial Temporal Lobe Familial Temporal Lobe Epilepsy
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12953	R-268712	Inhibitor	99.92%	Unkown
HY-117738	Benarthin	Inhibitor	95.79%	Unkown
HY-RS14511	THY1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106611	Brinazarone	Inhibitor	/	Unkown
HY-RS17457	Thy1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23914	Thy1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990157	Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1)	Inhibitor	95.00%	Unkown
HY-P990156	Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THY1	VGNC	VGNC:78352
Rattus norvegicus	THY1	RGD	RGD:3860
Felis catus	THY1	VGNC	VGNC:104334
Canis familiaris	THY1	VGNC	VGNC:47362
Mus musculus	THY1	MGD	MGI:98747
Bos taurus	THY1	VGNC	VGNC:35856
Others	THY1	NCBI