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Tlr6 - toll-like receptor 6 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21899

About Tlr6

Chromosome 5: 65,109,374-65,117,440 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 190 orthologues, 23 paralogues and is associated with 9 phenotypes. Broad expression in spleen adult (RPKM 3.6), colon adult (RPKM 1.8) and 17 other tissues.

Summary

Enables diacyl Lipopeptide binding activity. Involved in several processes, including positive regulation of biosynthetic process; regulation of cytokine production; and Toll-like Receptor signaling pathway. Part of Toll-like Receptor 2-Toll-like receptor 6 protein complex. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Tlr6 Products (6)

mRNA	Protein	Name
NM_001359180.2	NP_001346109.2	toll-like receptor 6 precursor
NM_001384171.1	NP_001371100.1	toll-like receptor 6 precursor
NM_011604.5	NP_035734.4	toll-like receptor 6 precursor
NM_001359180.2	NP_001346109.2	toll-like receptor 6 precursor
NM_001384171.1	NP_001371100.1	toll-like receptor 6 precursor
NM_011604.5	NP_035734.4	toll-like receptor 6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables diacyl lipopeptide binding	IDA IDA: Inferred from direct assay	19931471	MGI
enables lipopeptide binding	IMP IMP: Inferred from mutant phenotype	11431423	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19931471	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in MyD88-dependent toll-like receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in TRIF-dependent toll-like receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	22198949	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23812099	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	23812099	MGI
involved in positive regulation of macrophage activation	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of nitric oxide biosynthetic process	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	20037584	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Toll-like receptor 2-Toll-like receptor 6 protein complex	IDA IDA: Inferred from direct assay	19931471	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr6 Protein Structure

LRR_RI

PLN00113

LRR_1

LRR_8

LRR_1

LRR_RI

LRRCT

TIR

0
200
400
600
795 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 6

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10586	Macrophage-activating lipopeptide 2	Activator	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2036A	FSL-1 TFA	Agonist	99.81%	Unkown
HY-P2036	FSL-1	Agonist	99.22%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr6	NCBI	NCBI:10333