Tnfrsf11a - tumor necrosis factor receptor superfamily, member 11a, NFKB activator Gene

Also Known as OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21934

About Tnfrsf11a

Chromosome 1: 105,708,443-105,775,709 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 493 orthologues, 21 paralogues and is associated with 51 phenotypes. Biased expression in colon adult (RPKM 2.9), duodenum adult (RPKM 8.1) and 1 other tissues.

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF Receptor Superfamily member 11a). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11a Products (1)

mRNA Protein Name
NM_009399.5 NP_033425.3 tumor necrosis factor receptor superfamily member 11A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10097072 MGI
enables tumor necrosis factor receptor activity IMP
IMP: Inferred from mutant phenotype
19940926 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian temperature homeostasis IMP
IMP: Inferred from mutant phenotype
19940926 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
10500098 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
11051546 MGI
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
10500098 MGI
acts upstream of or within multinuclear osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
11805147 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
10500098 MGI
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
19940926 MGI
acts upstream of or within positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
11805147 MGI
involved in positive regulation of fever generation by positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
19940926 MGI
involved in positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
23478294 MGI
involved in response to interleukin-1 IMP
IMP: Inferred from mutant phenotype
19940926 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19940926 MGI
involved in response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
19940926 MGI
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
19940926 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21844205 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
23478294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnfrsf11a Protein Structure

TNFRSF11A

TNFRSF11A: cd13411 (33 - 195)

TNFRSF11A

TNFRSF11A: cd13411 (34 - 68)

TNFRSF11A

TNFRSF11A: cd13411 (71 - 112)

TNFRSF11A

TNFRSF11A: cd13411 (114 - 151)

TNFRSF11A

TNFRSF11A: cd13411 (154 - 194)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 625 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 11A

  • osteoclast differentiation factor receptor

  • receptor activator of NF-KB

  • receptor activator of NF-kappaB

Tnfrsf11a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tnfrsf11a O35305 Traf6 Mus musculus P70196
Anti Bait CoIP
10097072
Intra
Tnfrsf11a O35305 Traf3 Mus musculus Q60803
Y2H
15102471
Intra
Tnfrsf11a O35305 Bag6 Mus musculus Q9Z1R2
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tnfrsf11a Proteins

Cat. No. Product Name Accession Purity
HY-P72483 RANK/TNFRSF11A Protein, Mouse (HEK293, His) O35305 (V31-S214) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14800 Tnfrsf11a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14801 Tnfrsf11a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14799 TNFRSF11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf11a NCBI NCBI:8792