Trex1 - three prime repair exonuclease 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22040

Summary

Enables several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; cellular response to cytokine stimulus; and regulation of generation of precursor metabolites and energy. Located in cytosol; endoplasmic reticulum; and nuclear replication fork. Part of oligosaccharyltransferase complex and protein-DNA complex. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Trex1 Products (2)

mRNA Protein Name
NM_001012236.1 NP_001012236.1 three-prime repair exonuclease 1
NM_011637.6 NP_035767.4 three-prime repair exonuclease 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IMP
IMP: Inferred from mutant phenotype
15254239 MGI
enables 3'-5'-DNA exonuclease activity IDA
IDA: Inferred from direct assay
11279105 MGI
enables DNA binding IDA
IDA: Inferred from direct assay
20871604 MGI
enables DNA binding, bending IDA
IDA: Inferred from direct assay
25848017 MGI
enables WW domain binding IDA
IDA: Inferred from direct assay
17355961 MGI
enables adenyl deoxyribonucleotide binding IDA
IDA: Inferred from direct assay
17293595 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
19158679 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
17293595 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
25848017 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11279105 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
11279105 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
17293595 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CD86 biosynthetic process IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within DNA catabolic process IDA
IDA: Inferred from direct assay
20871604 MGI
acts upstream of or within DNA catabolic process IMP
IMP: Inferred from mutant phenotype
18724932 MGI
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
18045533 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
20511593 MGI
acts upstream of or within DNA duplex unwinding IDA
IDA: Inferred from direct assay
25848017 MGI
involved in DNA metabolic process IDA
IDA: Inferred from direct assay
11279105 MGI
acts upstream of or within DNA modification IMP
IMP: Inferred from mutant phenotype
24205360 MGI
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
20511593 MGI
acts upstream of or within DNA synthesis involved in UV-damage excision repair IMP
IMP: Inferred from mutant phenotype
23993650 MGI
acts upstream of or within G2 phase IMP
IMP: Inferred from mutant phenotype
18045533 MGI
acts upstream of or within T cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within activation of immune response IMP
IMP: Inferred from mutant phenotype
18045533 MGI
acts upstream of or within adaptive immune response IMP
IMP: Inferred from mutant phenotype
25848017 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within atrial cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
15254239 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
25848017 MGI
acts upstream of or within cellular response to UV IDA
IDA: Inferred from direct assay
20511593 MGI
acts upstream of or within cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
18045533 MGI
acts upstream of or within cellular response to hydroxyurea IMP
IMP: Inferred from mutant phenotype
18045533 MGI
acts upstream of or within cellular response to interferon-beta IDA
IDA: Inferred from direct assay
19158679 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23993650 MGI
acts upstream of or within cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
23993650 MGI
acts upstream of or within cellular response to type I interferon IMP
IMP: Inferred from mutant phenotype
28835460 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
20871604 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
15254239 MGI
acts upstream of or within establishment of protein localization IMP
IMP: Inferred from mutant phenotype
23160154 MGI
acts upstream of or within generation of precursor metabolites and energy IMP
IMP: Inferred from mutant phenotype
28069950 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
15254239 MGI
acts upstream of or within heart process IMP
IMP: Inferred from mutant phenotype
15254239 MGI
acts upstream of or within immune complex formation IMP
IMP: Inferred from mutant phenotype
25848017 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
28835460 MGI
acts upstream of or within immune response in brain or nervous system IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response IMP
IMP: Inferred from mutant phenotype
25848017 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15254239 MGI
acts upstream of or within inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within innate immune response IMP
IMP: Inferred from mutant phenotype
23160154 MGI
acts upstream of or within interferon-alpha production IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
25848017 MGI
acts upstream of or within lymphoid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
25848017 MGI
acts upstream of or within macrophage activation involved in immune response IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
18045533 MGI
acts upstream of or within negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18724932 MGI
acts upstream of or within organ or tissue specific immune response IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within protein stabilization IDA
IDA: Inferred from direct assay
26320659 MGI
acts upstream of or within regulation of T cell activation IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
23160154 MGI
acts upstream of or within regulation of cellular metabolic process IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within regulation of cellular metabolic process IMP
IMP: Inferred from mutant phenotype
28069950 MGI
acts upstream of or within regulation of cellular respiration IMP
IMP: Inferred from mutant phenotype
28069950 MGI
acts upstream of or within regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
28069950 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23160154 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23160154 MGI
acts upstream of or within regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
28069950 MGI
acts upstream of or within regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
26320659 MGI
acts upstream of or within regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
20871604 MGI
acts upstream of or within regulation of lipid biosynthetic process IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within regulation of lysosome organization IMP
IMP: Inferred from mutant phenotype
23160154 MGI
acts upstream of or within regulation of protein complex stability IMP
IMP: Inferred from mutant phenotype
26320659 MGI
acts upstream of or within regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
24218451 MGI
acts upstream of or within regulation of type I interferon production IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
20871604 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
28351661 MGI
acts upstream of or within retrotransposition IMP
IMP: Inferred from mutant phenotype
28835460 MGI
acts upstream of or within type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
28351661 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17355961 MGI
located in cytosol IDA
IDA: Inferred from direct assay
28351661 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18724932 MGI
located in nuclear replication fork IDA
IDA: Inferred from direct assay
18045533 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18045533 MGI
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
26320659 MGI
part of protein-DNA complex IDA
IDA: Inferred from direct assay
25848017 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

three-prime repair exonuclease 1

  • 3'-5' exonuclease TREX1

  • DNase III

  • three prime exonuclease 1

  • trophoblast expressed 1

Trex1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87119 TREX1 Antibody (YA6812) WB, FC, IP Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160785 TREX1-IN-1 Modulator 99.32% Unkown
HY-RS15008 TREX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160786 TREX1-IN-3 Inhibitor / Unkown
HY-160786A TREX1-IN-4 Inhibitor / Unkown
HY-RS17776 Trex1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24243 Trex1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trex1 NCBI NCBI:11277