UCMA - upper zone of growth plate and cartilage matrix associated Gene

Also Known as GRP; C10orf49; GRP/UCMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221044

About UCMA

This gene has 2 transcripts (splice variants) and 220 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

UCMA Products (3)

mRNA Protein Name
NM_001303118.2 NP_001290047.1 unique cartilage matrix-associated protein isoform 2 precursor
NM_001303119.2 NP_001290048.1 unique cartilage matrix-associated protein isoform 3 precursor
NM_145314.3 NP_660357.2 unique cartilage matrix-associated protein isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables BMP binding IDA
IDA: Inferred from direct assay
29563538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29720262 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unique cartilage matrix-associated protein

  • Gla-rich protein

Recombinant UCMA Proteins

Cat. No. Product Name Accession Purity
HY-P71413 UCMA Protein, Human Q8WVF2 (S65-T138) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Poland Syndrome

  • Poland Anomaly

  • Poland Sequence

  • Poland Syndactyly

  • Poland'S Syndrome

  • Poland'S Anomaly

  • Poland'S Syndactyly

  • Acro-Pectoro-Renal Field Defect

  • Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys

  • Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand

  • Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132595 Teprasiran p53 Inhibitor / Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179573 UCM-A86 Modulator 98.64% Unkown
HY-RS15406 UCMA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19968 Ucma Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26471 Ucma Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UCMA MGD MGI:1915777
Macaca mulatta UCMA VGNC VGNC:79482
Bos taurus UCMA VGNC VGNC:107012
Canis familiaris UCMA VGNC VGNC:48107
Rattus norvegicus UCMA RGD RGD:1308977
Others UCMA NCBI