UCMA - upper zone of growth plate and cartilage matrix associated Gene

Homo sapiens

Also known as GRP; C10orf49; GRP/UCMA

Gene ID: 221044 | Gene type: protein coding

About UCMA

This gene has 2 transcripts (splice variants) and 220 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

UCMA Products(3)

mRNA	Protein	Name
NM_001303118.2	NP_001290047.1	unique cartilage matrix-associated protein isoform 2 precursor
NM_001303119.2	NP_001290048.1	unique cartilage matrix-associated protein isoform 3 precursor
NM_145314.3	NP_660357.2	unique cartilage matrix-associated protein isoform 1 preproprotein

Protein Preferred Names

Protein Names

unique cartilage matrix-associated protein

Gla-rich protein

Recombinant UCMA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71413	UCMA Protein, Human	Q8WVF2 (S65-T138)	≥95%

Related Diseases

Diseases

Alias

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Poland Syndrome

Poland Anomaly	Poland Sequence
Poland Syndactyly	Poland'S Syndrome
Poland'S Anomaly	Poland'S Syndactyly
Acro-Pectoro-Renal Field Defect	Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys
Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand	Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132595	Teprasiran	p53 Inhibitor	90.25%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15406	UCMA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UCMA	MGD	MGI:1915777
Macaca mulatta	UCMA	VGNC	VGNC:79482
Bos taurus	UCMA	VGNC	VGNC:107012
Canis familiaris	UCMA	VGNC	VGNC:48107
Rattus norvegicus	UCMA	RGD	RGD:1308977
Others	UCMA	NCBI

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