BEND6 - BEN domain containing 6 Gene

Also Known as C6orf65

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221336

About BEND6

This gene has 4 transcripts (splice variants) and 106 orthologues. Biased expression in brain (RPKM 5.4), gall bladder (RPKM 1.0) and 7 other tissues.

Summary

Enables transcription corepressor activity. Predicted to be involved in negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

BEND6 Products (2)

mRNA Protein Name
NM_001318539.2 NP_001305468.1 BEN domain-containing protein 6 isoform 2
NM_152731.3 NP_689944.2 BEN domain-containing protein 6 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
23571214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEND6 Protein Structure

BEN

BEN: BEN domain (191 - 269)

  • 0
  • 100
  • 200
  • 279 a.a.
Protein Preferred Names Protein Names

BEN domain-containing protein 6

Related Diseases

Diseases Alias
Extratemporal Epilepsy
Carpenter Syndrome 1

  • Carpenter Syndrome

  • Acrocephalopolysyndactyly Type Ii

  • Acps Ii

  • CRPT1

  • Acrocephalopolysyndactyly Type 2

  • Acrocephalosyndactyly, Type Ii

  • Acrocephalopolysyndactyly 2

  • Acps2

  • Acps 2

  • Type Ii Acrocephalosyndactyly

  • Carpenter Syndrome, Type 1

  • Apert-Crouzon Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01472 BEND6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BEND6 RGD RGD:1310392
Canis familiaris BEND6 VGNC VGNC:38432
Macaca mulatta BEND6 VGNC VGNC:70355
Bos taurus BEND6 VGNC VGNC:26469
Mus musculus BEND6 MGD MGI:2444572
Felis catus BEND6 VGNC VGNC:60102
Others BEND6 NCBI