SP8 - Sp8 transcription factor Gene

Homo sapiens

Also known as BTD

Gene ID: 221833 | Gene type: protein coding

About SP8

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,782,279-20,786,886 (from NCBI)

This gene has 2 transcripts (splice variants), 173 orthologues and 22 paralogues. Biased expression in prostate (RPKM 3.9) and skin (RPKM 0.2).

Summary

The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

SP8 Products(2)

mRNA	Protein	Name
NM_182700.6	NP_874359.2	transcription factor Sp8 isoform 1
NM_198956.4	NP_945194.1	transcription factor Sp8 isoform 2

SP8 Protein Structure

zf-H2C2_2

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

transcription factor Sp8

specificity protein 8

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 110

DFNB110	Autosomal Recessive Nonsyndromic Deafness 110
Autosomal Recessive Deafness 110	Deafness, Autosomal Recessive, 110

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120994B	Sp-8-CPT-cAMPS	Activator	/	Unkown
HY-137640A	Sp-8-Br-cAMPS sodium	Agonist	/	Unkown
HY-RS13611	SP8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SP8	VGNC	VGNC:35158
Macaca mulatta	SP8	VGNC	VGNC:77964
Mus musculus	SP8	MGD	MGI:2443471
Felis catus	SP8	VGNC	VGNC:102707
Rattus norvegicus	SP8	RGD	RGD:1307619
Others	SP8	NCBI

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