TMED4 - transmembrane p24 trafficking protein 4 Gene

Also Known as HNLF; ERS25; p24a3; GMP25iso; p24alpha3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222068

About TMED4

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,577,894-44,582,231 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 37.8), small intestine (RPKM 27.8) and 25 other tissues.

Summary

Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED4 Products (6)

mRNA Protein Name
NM_001303058.2 NP_001289987.1 transmembrane emp24 domain-containing protein 4 isoform 2 precursor
NM_001303059.2 NP_001289988.1 transmembrane emp24 domain-containing protein 4 isoform 3 precursor
NM_001303060.2 NP_001289989.1 transmembrane emp24 domain-containing protein 4 isoform 4
NM_001303061.2 NP_001289990.1 transmembrane emp24 domain-containing protein 4 isoform 5
NM_001303062.2 NP_001289991.1 transmembrane emp24 domain-containing protein 4 isoform 5
NM_182547.4 NP_872353.2 transmembrane emp24 domain-containing protein 4 isoform 1 precursor

TMED4 Protein Structure

EMP24_GP25L

EMP24_GP25L: emp24/gp25L/p24 family/GOLD (30 - 222)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

transmembrane emp24 domain-containing protein 4

  • endoplasmic reticulum stress-response protein 25 kDa

Recombinant TMED4 Proteins

Cat. No. Product Name Accession Purity
HY-P77242 TMED4 Protein, Human (HEK293, His) Q7Z7H5-1 (L30-R194) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77243 TMED4 Protein, Human (HEK293, Fc) Q7Z7H5-1 (L30-R194) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ceroid Lipofuscinosis, Neuronal, 8

  • Neuronal Ceroid Lipofuscinosis 8

  • CLN8

  • Cln8 Disease

  • Epilepsy Mental Deterioration Finnish Type

  • Northern Epilepsy

  • Cln8 Disease, Epmr

  • Cln8 Disease, Northern Epilepsy Variant

  • Cln8 Disease, Late Infantile

  • Ceroid Lipofuscinosis Neuronal 8

  • Ncl, Northern Epilepsy Variant

  • Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

  • Progressive Epilepsy - Intellectual Disability, Finnish Type

  • Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type

  • Turkish Variant Late Infantile Ncl

  • Ceroid Lipofuscinosis, Neuronal 8

  • Lipofuscinosis, Ceroid, Neuronal, Type 8

  • Northern Epilepsy Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14638 TMED4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20501 Tmed4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27009 Tmed4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TMED4 VGNC VGNC:35937
Macaca mulatta TMED4 VGNC VGNC:79352
Mus musculus TMED4 MGD MGI:1915070
Rattus norvegicus TMED4 RGD RGD:1306319
Canis familiaris TMED4 VGNC VGNC:47439
Felis catus TMED4 VGNC VGNC:66249
Others TMED4 NCBI