Ube2b - ubiquitin-conjugating enzyme E2B Gene

Also Known as HR6B; E214K; Rad6b; mHR6B; E2-14k

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22210

Summary

Enables ubiquitin conjugating enzyme activity and ubiquitin protein Ligase binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including chromosome organization; positive regulation of reciprocal meiotic recombination; and sperm axoneme assembly. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human UBE2B (Ubiquitin Conjugating Enzyme E2 B). [provided by Alliance of Genome Resources, Apr 2022]

Ube2b Products (3)

mRNA Protein Name
NM_001362685.1 NP_001349614.1 ubiquitin-conjugating enzyme E2 B isoform 1
NM_001362686.1 NP_001349615.1 ubiquitin-conjugating enzyme E2 B isoform 2
NM_009458.5 NP_033484.3 ubiquitin-conjugating enzyme E2 B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12509447 MGI
enables ubiquitin conjugating enzyme activity IGI
IGI: Inferred from genetic interaction
14585983 MGI
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
14585983 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
12556476 MGI
acts upstream of or within chiasma assembly IMP
IMP: Inferred from mutant phenotype
12556476 MGI
acts upstream of or within chromatin organization IMP
IMP: Inferred from mutant phenotype
17488778 MGI
acts upstream of ectopic germ cell programmed cell death IMP
IMP: Inferred from mutant phenotype
12556476 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
15169909 MGI
acts upstream of or within leptotene IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12556476 MGI
acts upstream of or within negative regulation of developmental process IMP
IMP: Inferred from mutant phenotype
12556476 MGI
acts upstream of or within negative regulation of post-translational protein modification IMP
IMP: Inferred from mutant phenotype
17488778 MGI
acts upstream of or within negative regulation of reproductive process IMP
IMP: Inferred from mutant phenotype
12556476 MGI
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18339854 MGI
acts upstream of or within positive regulation of reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
12556476 MGI
acts upstream of or within sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
12672659 MGI
acts upstream of or within synaptonemal complex organization IMP
IMP: Inferred from mutant phenotype
12556476 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
15383616 MGI
located in chromatin IDA
IDA: Inferred from direct assay
15383616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 B

  • E2 ubiquitin-conjugating enzyme B

  • RAD6 homolog B

  • ubiquitin carrier protein B

  • ubiquitin-conjugating enzyme E2B, RAD6 homology

  • ubiquitin-protein ligase B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15337 UBE2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20506 Ube2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27014 Ube2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ube2b NCBI NCBI:7320