NAPEPLD - N-acyl phosphatidylethanolamine phospholipase D Gene

Also Known as FMP30; C7orf18; NAPE-PLD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222236

About NAPEPLD

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,099,776-103,150,001 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele and 220 orthologues. Ubiquitous expression in brain (RPKM 8.2), kidney (RPKM 8.2) and 25 other tissues.

Summary

NAPEPLD is a Phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

NAPEPLD Products (21)

mRNA Protein Name
NM_001122838.3 NP_001116310.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386176.1 NP_001373105.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386177.1 NP_001373106.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386179.1 NP_001373108.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386182.1 NP_001373111.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386185.1 NP_001373114.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386189.1 NP_001373118.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 4
NM_001386190.1 NP_001373119.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386191.1 NP_001373120.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386193.1 NP_001373122.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386194.1 NP_001373123.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386204.1 NP_001373133.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386205.1 NP_001373134.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2
NM_001386207.1 NP_001373136.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2
NM_001386208.1 NP_001373137.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386209.1 NP_001373138.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386210.1 NP_001373139.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 3
NM_001386211.1 NP_001373140.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2
NM_001386212.1 NP_001373141.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386213.1 NP_001373142.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_198990.6 NP_945341.3 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IDA
IDA: Inferred from direct assay
25684574 GOA
enables bile acid binding IDA
IDA: Inferred from direct assay
27571266 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25684574 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
25684574 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
25684574 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
25684574 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPEPLD Protein Structure

Lactamase_B_2

Lactamase_B_2: Beta-lactamase superfamily domain (144 - 344)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

  • NAPE-hydrolyzing phospholipase D

NAPEPLD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAPEPLD Q6IQ20 NAPEPLD Homo sapiens Q6IQ20
Comig Non-Denat Gel
25684574
Intra
NAPEPLD Q6IQ20 NAPEPLD Homo sapiens Q6IQ20
GMS
25684574
Intra
NAPEPLD Q6IQ20 NAPEPLD Homo sapiens Q6IQ20
X-Ray Diffraction
25684574
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vulvar Syringoma
Cannabis Abuse

  • Marijuana Abuse
Cannabis Dependence

  • Marijuana Abuse

  • Cannabinoid Addiction

  • Cannabinoid Dependence

  • Cannabis Addiction
Hallucinogen Dependence

  • Hallucinogen Addiction
Lennox-Gastaut Syndrome

  • Lennox Syndrome

  • Encephalopathy Of Childhood

  • Epileptic Encephalopathy Lennox-Gastaut Type

  • Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

  • Lgs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131181 LEI-401 Inhibitor 99.73% Unkown
HY-155773 VU534 Inhibitor 98.10% Unkown
HY-155774 VU533 99.84% Unkown
HY-118994 ARN19874 Inhibitor 99.54% Unkown
HY-RS09031 NAPEPLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22012 Napepld Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28530 Napepld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAPEPLD VGNC VGNC:31883
Rattus norvegicus NAPEPLD RGD RGD:735197
Felis catus NAPEPLD VGNC VGNC:63721
Canis familiaris NAPEPLD VGNC VGNC:43621
Mus musculus NAPEPLD MGD MGI:2140885
Macaca mulatta NAPEPLD VGNC VGNC:75001
Others NAPEPLD NCBI